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Completed

NCT Number: NCT06005129

Personality Change Study for Borderline Personality Disorder

Participants with borderline personality disorder will undergo an a 2 - 4 week baseline assessment to determine level of outcomes of interest in the absence of treatment. After the baseline period, participants will receive six weekly 50-60-minute treatment sessions. After the 6 treatment sessions, participants will complete a 4-week follow-up period to determine the sustainability of the treatment module.

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Key information

Conditions

Borderline Personality Disorder Mental Disorders Personality Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinic for Emotional Health at the University of Kentucky

Lexington, Kentucky, 40508-2307, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Speak English fluently
  • Diagnosis of Borderline Personality Disorder

Exclusion criteria

  • diagnosed psychological conditions that would be better addressed by alternative treatments
  • concurrent psychotherapy
  • medication instability
  • substance use disorder

Treatment and study plan

Personality-Based Therapy

Behavioral

Participants will be randomized to a 2- or 4-week assessment-only baseline period. After the baseline period, participants will receive the personality-based treatment module corresponding to their highest clinical elevation (i.e., neuroticism, [low] conscientiousness, [low] agreeableness). Treatment will consist of six weekly 50-60-minute sessions. After the 6-week intervention period, participants will complete a 4-week follow-up period to determine the sustainability of effects observed

Primary outcomes

  1. Change in clinician-rated borderline personality disorder symptoms

    Time frame: up to 14 weeks (pre-baseline, pre-intervention, post-intervention, post-follow-up)

    Change in borderline personality disorder symptoms will be measured using Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) - clinician-rated version. Scores range from 0-36; higher scores indicate greater severity of borderline personality disorder symptoms

  2. Change in patient-reported borderline personality disorder symptoms

    Time frame: weekly up to 14 weeks

    Change in borderline personality disorder symptoms will be measured using Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) - self-report version. Scores range from 0-36; higher scores indicate greater severity of borderline personality disorder symptoms

Sponsors and collaborators

Lead sponsor

Shannon E. Sauer-Zavala

Other

Collaborators

  • American Psychological Foundation
  • National Institute of Mental Health (NIMH)

Registry information

Official study title

Engaging Higher-Order Mechanisms of Psychopathology: A Parsimonious Approach to Precision Medicine

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Aug 22, 2023
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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