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Completed

NCT Number: NCT02547246

Transcranial Magnetic Stimulation and Bulimic Craving

Bulimic patients suffering from binge eating or "craving" a pressing need to eat, with a sense of unease and anxiety, relieved by food intake. The phenomenon of craving bulimia may be considered appropriately by using paradigms developed in the framework of embodied cognition theories.

In bulimic, a study with 20 bulimic patients proved an automatic attraction (unconscious) for food in these patients, as measured by reaction time.

Moreover, a therapeutic explored in bulimia (particularly on reducing craving), is repeated transcranial magnetic stimulation (rTMS). Studies have shown that a single session of rTMS to the dorsolateral prefrontal cortex left (DLPFC) reduces significantly the food craving among bulimics, 24 hours after stimulation. But the therapeutic efficacy of TMS on bulimia to more than 24 hours has not yet been demonstrated, and the psycho-cognitive underlying mechanisms have not yet been explored.

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Key information

Conditions

Bulimia Hyperphagia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

CHU de SAINT-ETIENNE

Saint-Etienne, 42000, France

About this study

The exams / treatments of the study include:

  • a 20 minute session of rTMS at a frequency of 10 Hz.
  • cognitive testing and attention, which will be made on the computer before and 24 hours after the session of rTMS.

Cognitive test consist in , on a computer screen:

  • Is first displayed, food and non-food words. The patient must pull a lever to it if the letter A is present in the word and push the lever if the letter A is missing the word.
  • Then presents a series of food and non-food words. The patient must pull a lever to it if it deems that the word has a positive meaning and push the lever if it determines that the word has a negative meaning

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • right-handed patient
  • Patients without psychotropic treatment or treatment with a stable and unchanged for over a month.
  • Normal BMI

Exclusion criteria

  • Previous history of seizures or epilepsy.
  • Participants with a somatic problem restricted movement or an uncorrected visual acuity problem.
  • History of head trauma, neurological disease or unstabilized serious physical illness.
  • Major Depressive Episode at the time of the study

Treatment and study plan

rTMS session

Device

One session of rTMS at a frequency of 10 Hz during 20 minutes

rTMS Placebo (SHAM)

Device

One session of placebo (SHAM) rTMS during 20 minutes

Primary outcomes

  1. Motor response time

    Time frame: 24h after rTMS session

    time taken to pull or push the lever in cognitive tests (composite measure)

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Registry information

Official study title

Transcranial Magnetic Stimulation, Embodied Cognition and Bulimic Craving

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Sep 11, 2015
Registry last updated
Mar 23, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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