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Completed

NCT Number: NCT04211818

Analysis of the Glycemic Profile of People Suffering From Compulsive Eating Disorders Aiming to Offer an Innovative Nutritional Approach (GLUCOPULSE)

Eating Disorders (ED) are a major public health problem. Current care remains only partially effective and the pathophysiology of the disorders remains to be deepened. With regard to compulsive ED (bulimia and binge eating disorder), our clinical experience suggests that one of the major triggers for crisis may be related to glycemia. In fact, bulimia could be considered as a vicious circle where the binge eating disorder is going to be followed by a food restriction in order to control weight , putting the subject in a situation of "energy deficiency" which will favor the emergence of new crises . Technological advances have resulted in the emergence of new measuring devices, such as "tracking", which records continuous glycemia, which would allow us to explore these clinical hypotheses.

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Key information

Conditions

Bulimia Behavior Binge Eating Blood Glucose, Low Compulsion Compulsive Behavior Crisis State Hyperphagia Impulsive Behavior Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital

Montpellier, 34 295, France

About this study

This is an open-label, exploratory, proof-of-concept study.

20 patients will be recruited from the day hospital of the Endocrinology and Nutrition Department of the University Hospital of Montpellier, Lapeyronie and from Emergencies and Post-psychiatric Emergencies Department.

During the inclusion visit, the dietician will explain to the patient the use of the dietary book and the glycemic sensor which will be allocated to it. The patient will also answer to self-questionnaires about his eating behavior.

No nutritional approach will be addressed so as not to alter the patient's eating behavior and not to influence the results.

They will be followed-up during 14 days.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subject suffering from eating disorders with at least 3 episodes of bulimia per week for at least 2 months
  • Subject affiliated to a health insurance or beneficiary of such a plan
  • Subject able to understand the nature, purpose and methodology of the study
  • Subject signed informed consent

Exclusion criteria

  • Subject suffering from eating disorders such as anorexia nervosa
  • Subject unable according to the investigator's opinion to keep updated a dietary book or to perform correctly the glycemic recordings
  • Subject suffering from somatic pathology (ex: diabetes) or psychiatric pathology assessed by the MINI (ex : severe current major depressive episode) that may interfere with the protocol according to the the investigator
  • Major subject legally protected (guardians or curators) or deprived of freedom by judicial or administrative order
  • Pregnant or nursing woman

Treatment and study plan

Eating Behavior

Behavioral

A dietary book will be given to the patient and will be filled by this one during 14 days

Blood glucose records

Biological

A glycemic sensor will be placed at the back of the patient's arm

Primary outcomes

  1. Frequency of episodes of bulimia (measured from the dietary book) according to the interstitial glucose levels

    Time frame: At the return of the dietary book (14 days after enrollment)

    Each information entered on the dietary book will be positioned on a chronological axis allowing to identify precisely when the eating disorder occurred

Secondary outcomes

  1. Levels of impulse to make a crisis and food obsession and hunger depending on interstitial glucose levels

    Time frame: At the return of the dietary book (14 days after enrollment)

    Each information entered on the dietary book will be positioned on a chronological axis allowing to identify precisely when the eating disorder occurred

  2. Dietary patterns

    Time frame: At enrollment

    Measured by the Emotional Appetite Questionnaire (EMAQ), 1 represent a food intake much smaller than usual ; 9 represent a food intake more significant than usual ; 5 represent a food intake as usual

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Official study title

Analysis of the Glycemic Profile of People Suffering From Compulsive Eating Disorders Aiming to Offer an Innovative Nutritional Approach

Acronym: GLUCOPULSE

Important dates

Study start
2020
Primary completion
2022
Study completion
2023
First posted
Dec 26, 2019
Registry last updated
Sep 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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