Transcorneal Electrical Stimulation Therapy for Retinal Disease

Transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.

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Key information

Conditions

Retinitis Pigmentosa Arterial Occlusive Diseases Cardiovascular Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Cranial Nerve Diseases Dry Age Related Macular Degeneration Embolism and Thrombosis Eye Diseases Eye Diseases, Hereditary Genetic Diseases, Inborn Glaucoma Glaucoma, Open-Angle Hereditary Autosomal Dominant Optic Atrophy Hereditary Macular Degeneration Heredodegenerative Disorders, Nervous System Ischemic Macula Edema Macula Off Metabolic Diseases Mitochondrial Diseases Nervous System Diseases Neurodegenerative Diseases Non-Arthritic-Anterior-Ischemic Optic-Neuropathy Nutritional and Metabolic Diseases Ocular Hypertension Optic Atrophies, Hereditary Optic Atrophy Optic Atrophy, Autosomal Dominant Optic Nerve Diseases Primary Open Angle Glaucoma Retinal Artery Occlusion Retinal Degeneration Retinal Diseases Retinal Dystrophies Retinal Vein Occlusion Thrombosis Treated Retina Detachment Vascular Diseases Venous Thrombosis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Retinitis pigmentosa, Macula off, Primary open angle Glaucoma, Hereditary Macular Degeneration, Treated Retina detachment, Retinal Artery Occlusion, Retinal Vein Occlusion, Non-Arthritic-Anterior-Ischemic Optic-Neuropathy, Hereditary autosomal dominant Optic atrophy, dry Age-related Macular Degeneration, Ischemic Macula edema

Exclusion criteria

Severe other disease such as non-proliferative diabetic retinopathy, exudative Age-related Macular Degeneration
Age above 99 years

Treatment and study plan

Transcorneal Electrical Stimulation

Device

Neurostimulator drives Dawson-Trick-Litzkow electrode attached to patient eye. Different modi are used to stimulate patients.

DTL-electrode attached without energy

Device

DTL-electrode attached to patient eye receives no energy from neurostimulator. Treatment times remain the same as used for each treatment arm.

Primary outcomes

enhanced field of vision, enhanced visual acuity, lower threshold for electrical evoked phosphenes

Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Okuvision GmbH

Industry

Registry information

Official study title

Transcorneal Electrical Stimulation Therapy for Retinal Disease - A Randomized, Single-blind Pilot Study

Important dates

Study start: 2008
Primary completion: 2011
Study completion: 2011
First posted: Dec 8, 2008
Registry last updated: May 4, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed