Tranexamic Acid in Hip Fracture Surgery

To determine if TXA utilization is effective at reducing transfusion rates in elderly patients undergoing surgery for treatment of a hip fractures.

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Key information

Conditions

Hip Fracture Femoral Fractures Fractures, Bone Hip Fractures Hip Injuries Leg Injuries Wounds and Injuries

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Acute, isolated, unilateral femoral neck, intertrochanteric, and per trochanteric hip fractures confirmed by anteroposterior/lateral hip radiographs, computed tomography, or magnetic resonance imaging.
Age 65 and older
Low energy mechanism of injury
Hip fracture fixation performed within 48 hours
English speaking
Anticipated medical optimization for operative fixation
No other major trauma

Exclusion criteria

Retained hardware around the affected hip
Infection around the affected hip
Transfer patients with a length of stay > 24 hours at the transferring hospital
Diagnosis of deficient natural anticoagulation
Known congenital thrombophilia (Deficiency of Protein C, S, Antithrombin)
Known allergy to TXA
Patients undergoing percutaneous pinning of the hip fracture

Treatment and study plan

Primary outcomes

Blood Transfusion Rate

Time frame: 6 weeks

Blood transfusion rates during the patients hospital stay will be assessed.

Secondary outcomes

Hospital Length of stay

Time frame: 6 weeks

The patients length of stay in the hospital will be determined.
Post operative complications

Time frame: 6 weeks

Post operative complications will be assessed through the 6 weeks.
Hospitalization costs

Time frame: 6 weeks

Economic evaluation for inpatient and re-admission will be assessed.

Sponsors and collaborators

Lead sponsor

Corewell Health West

Other

Registry information

Official study title

Effectiveness of Tranexamic Acid (TXA) in Reducing Blood Loss in Hip Fracture Surgery

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Apr 13, 2016
Registry last updated: Sep 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed