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Completed

NCT Number: NCT07534137

Effect of PENG Block on Postoperative Tramadol Consumption in Partial Hip Prosthesis Surgery

This study aims to evaluate the effect of ultrasound-guided pericapsular nerve group (PENG) block on postoperative tramadol consumption, pain scores, and clinical outcomes in patients undergoing partial hip prosthesis surgery. Patients aged 18-75 years scheduled for surgery under general anesthesia were divided into two groups: those receiving PENG block and those not receiving the block. Postoperative tramadol consumption within the first 24 hours, visual analog scale (VAS) and numeric rating scale (NRS) scores, hemodynamic parameters, additional analgesic requirements, and recovery characteristics were recorded and compared between groups. The findings of this study are expected to contribute to optimizing multimodal analgesia strategies in hip surgery.

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Key information

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gaziantep University Faculty Of Medicine

Gaziantep, 27310, Turkey (Türkiye)

About this study

Postoperative pain management in hip surgery remains a significant clinical challenge, particularly in elderly patients. Effective analgesia is essential to reduce opioid consumption, improve patient comfort, and enhance recovery. The pericapsular nerve group (PENG) block is a relatively new regional anesthesia technique that targets the articular branches of the femoral, obturator, and accessory obturator nerves, providing analgesia to the anterior hip capsule.

This prospective study was conducted to compare the clinical effects of PENG block in patients undergoing partial hip prosthesis surgery under general anesthesia. A total of 48 patients aged between 18 and 75 years were included and divided into two groups: the PENG group (Group P), which received ultrasound-guided PENG block with 20 mL of 0.5% bupivacaine after induction of general anesthesia, and the control group (Group K), which received general anesthesia alone.

Demographic data, intraoperative anesthetic requirements, and postoperative parameters were recorded. The primary outcome measure was total tramadol consumption within the first 24 hours after surgery. Secondary outcomes included postoperative pain scores (VAS and NRS), hemodynamic parameters (mean arterial pressure and heart rate), remifentanil consumption, need for additional analgesia, bispectral index (BIS) values, patient comfort score, modified Aldrete recovery score, Riker agitation-sedation scale, and incidence of complications such as nausea, vomiting, hypotension, hypertension, and arrhythmia.

The results of this study are intended to evaluate the effectiveness of PENG block as a component of multimodal analgesia and to determine its impact on opioid consumption and postoperative recovery in patients undergoing hip surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged between 18 and 75 years
  • Patients scheduled for partial hip prosthesis surgery
  • Patients classified as ASA physical status I-III
  • Patients who provided written informed consent

Exclusion criteria

  • Known allergy to local anesthetics
  • Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia
  • Infection at the injection site
  • Severe systemic disease (ASA IV or higher)
  • Cognitive impairment preventing reliable pain assessment
  • Refusal to participate in the study

Treatment and study plan

PENG block

Procedure

Ultrasound-guided pericapsular nerve group block performed with 20 mL of 0.5% bupivacaine after induction of general anesthesia.

General Anesthesia

Procedure

Standard general anesthesia administered without regional nerve block.

Primary outcomes

  1. Total Tramadol Consumption Within 24 Hours After Surgery

    Time frame: 24 hours postoperatively

    Total amount of tramadol (mg) consumed by patients during the first 24 hours after surgery.

Secondary outcomes

  1. Postoperative VAS Pain Scores

    Time frame: 0, 10, 30, 60 minutes and 2, 4, 6, 12, 24 hours postoperatively

    Visual Analog Scale (VAS) pain scores ranging from 0 to 10, where 0 indicates no pain and 10 indicates worst imaginable pain, measured at predefined postoperative time points.

  2. Postoperative NRS Pain Scores

    Time frame: 0, 10, 30, 60 minutes and 2, 4, 6, 12, 24 hours postoperatively

    Numeric Rating Scale (NRS) pain scores ranging from 0 to 10, where 0 indicates no pain and 10 indicates worst possible pain, measured at predefined postoperative time points.

  3. Intraoperative Remifentanil Consumption

    Time frame: Intraoperative period

    Total amount of remifentanil used during surgery.

  4. Additional Analgesic Requirement

    Time frame: 24 hours postoperatively

    Requirement for additional analgesic medication in the postoperative period.

  5. Postoperative Complications

    Time frame: 24 hours postoperatively

    Incidence of complications including nausea, vomiting, hypotension, hypertension, arrhythmia, and pruritus.

Sponsors and collaborators

Lead sponsor

University of Gaziantep

Other

Registry information

Official study title

Comparison of Postoperative Tramadol Consumption, Clinical Effects, and Side Effects in Patients With and Without PENG (Pericapsular Nerve Group) Block in Partial Hip Prosthesis Surgery

Acronym: PENG-PKP

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Apr 16, 2026
Registry last updated
Apr 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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