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OpenTrials
Completed

NCT Number: NCT05079945

Tractography and Diffusion Tensor Imaging of the Human Spinal Cord in Healthy Subjects : Anatomical Atlas

Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord. Indeed, the spinal fibers (whether they have a sensory or motor function) are all condensed in an extremely small volume. To date, there is no reliable technique to know the precise position of the spinal tracts specifically involved in the sensory and motor functions of the upper and lower limbs.

The purpose of this study is to evaluate the feasibility for differentiating spinal tracts by tractography from a cerebral Diffusion tensor imaging (DTI) Magnetic Resonance Imaging (MRI) sequence (associated with an anatomical sequence) by performing a stitching process with spinal cord DTI MRI sequence, in healthy subjects. The criterion of differentiation of the tracts will be assessed by highlighting already known cerebral tracts (cortico-spinal fibers, spinothalamic, posterior cord) and which will be monitored at the spinal level.

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Key information

Conditions

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dauleac Corentin

Bron, 69500, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient> 18 years old
  • Healthy volunteer
  • Social insured in France
  • Patient who signed the informed consent of the study

Exclusion criteria

  • Medical or surgical history of disease that may affect the central nervous system, or the spine
  • History of spine or spinal cord trauma.
  • Spinal osteoarthritis which can lead to a medullary hyper signal.
  • Contraindication to MRI: claustrophobia, pace-maker, defibrillator, metallic foreign bodies, etc.
  • Subjects benefiting from legal protection (curatorship, guardianship or safeguard of justice).
  • Pregnant and / or breastfeeding woman.

Treatment and study plan

Spinal cord Tractography in order to differentiate spinal tracts.

Procedure

Spinal cord tractography using DTI MRI sequences of the brain and spinal cord, in order to differentiate tracts at the spinal cord level; and by performing a stitching process between Brain and Spinal cord DTI sequences.

Primary outcomes

  1. Spinal tracts differentiation and identification

    Time frame: date of Tractography procedure (DTI MRI)

    Percentage of complete tracts identified among healthy volunteer

Secondary outcomes

  1. Spinal cord Tracts Atlas

    Time frame: 12 months (end of recruitment and exams)

    Elaboration of a tracts classification using a algorithm based on the type, the volume and the fraction of anisotropy and mean diffusivity of each tract

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: TRACTOCORD

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Oct 15, 2021
Registry last updated
Sep 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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