Skip to main content
OpenTrials
Completed

NCT Number: NCT02180932

Towards a Viral Etiology of Periodontal Disease in Relation to Radiotherapy Treatment of Head and Neck Cancers

The treatment of otolaryngology (OLR) cancer is based on surgery, radiation, sometimes used in combination with chemotherapy. Patients treated with radiotherapy have multiple oral diseases: mucositis, hyposalivation, tissue fibrosis, exacerbation of periodontitis. Over 70% of patients with head and neck cancers treated with radiotherapy have a lower level of dental clinical attachment and 92% have loose teeth or missing. The management of these oral complications is a priority in OLR oncology. The aim is to improve the oral health of patients to achieve a comfortable life acceptable and necessary for healing.

This project proposes to deepen the investigation with two main objectives:

1. To study in vivo the effect of radiation treatment on the evolution of the viral flora of the periodontium in a cohort of patients and matched controls. 2. To study in vitro the effects of irradiation on the replication EBV (herpesvirus) in producing websites lymphoepithelial tonsillar, and atypical dendritic cells associated with EBV that existence were recently discovered.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Periodontal Disease Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital saint Roch

Nice, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients ≥ 18 years
  • Patients treated with curative radiotherapy on tumor site or surgery for cancer of the oral cavity and / or oropharynx
  • Patients naive treatments for head and neck cancers
  • Patients affiliated or beneficiary of a social security scheme
  • Patients who gave informed consent in writing

Exclusion criteria

  • Patients treated with neoadjuvant chemotherapy, adjuvant or concomitant
  • Patients taking immunosuppressants after organ transplantation
  • Taking anticoagulants incompatible with dental samples (possible bleeding)
  • Patients edentulous and / or whose dental condition is incompatible with the dental samples

Treatment and study plan

periodontal pocket samples

Biological

Primary outcomes

  1. Measure of level of EBV nucleic acids

    Time frame: day 1

  2. Measure of level of EBV nucleic acids

    Time frame: day 180

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Jul 3, 2014
Registry last updated
Mar 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.