Evaluation of Photodynamic Therapy as an Adjunct to Non-surgical Treatment in Periodontitis in Smokers vs. Non-smokers

Patients with moderate periodontal destruction underwent mechanical debridement of the pathological changes from the periodontal pockets in one of the randomly selected quadrants and in another, also randomly selected, quadrant. In addition to non-surgical debridement, photodynamic therapy was applied. This comparison between two treatment options was evaluated between subjects who smoke and non-smokers.

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Key information

Conditions

Periodontal Disease Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

at least two teeth with periodontal pockets up to 4 mm

Exclusion criteria

less than two teeth with periodontal pockets

Treatment and study plan

Scaling and root planing plus placebo

Procedure

Non-surgical treatment of periodontal pockets

Other names: scaling and root planning

Photodynamic therapy (PDT)

Combination Product

Photodynamic therapy was applied to a previously treated pocket with non-surgical therapy

Primary outcomes

Periodontal pocket depth reduction

Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

University of Pristina

Other

Registry information

Official study title

Comparison of Photodynamic Therapy vs. Non-surgical Periodontal Treatment in Patients Who Smoke vs. Non-smokers

Important dates

Study start: 2015
Primary completion: 2015
Study completion: 2015
First posted: Jul 13, 2026
Registry last updated: Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed