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OpenTrials
Completed

NCT Number: NCT06836401

Topical Metronidazole vs Control in Reducing Periodontal Pockets in a Split Mouth Clinical Trial

The effect of both the mechanical treatment and the topical metronidazol in reduccing the inflammation and depth of the periodontal pockets were assessed on the first bicuspids.

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Key information

Conditions

Periodontal Disease Mouth Diseases Periodontal Diseases Periodontal Inflammation Periodontal Pocket Periodontitis Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Dental School of the Faculty of Medicine

Salamanca, 37007, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Periodontal patients with all first premolars suffering from moderate periodontal pockets (>4mm of probing depth)

Exclusion criteria

  • No patients received antibiotics nor periodontal treatment in the previous 6 months

Treatment and study plan

Root scaling

Procedure

Scaling and root planing is a deep cleaning below the gumline used to remove plaque and tartar that cover the root in the periodontal pockets. This intervention is carried out in both control and experimental sites

Topical Gel

Drug

A gel (experimental: metronidazole VS control: carbopol) is introduced in the recently cleaned periodontal pocket. The allocation of either experimental or control gel was distributed randomly, being masked both the patient and the clinician.

Primary outcomes

  1. Probing depth

    Time frame: Both one month and three months after root scaling

    Probing depth is assessed at 6 points around the first bicuspids (mesiovestibular, midvestibular, distovestibular, mesiolingual, midlingual, distolingual)

  2. Mieloperoxidase ng/mL

    Time frame: Both one and three months after root scaling

    The determination of the quantity of mieloperoxidase ng/mL was assessed from the crevicular fluid of the treated bicuspids

Sponsors and collaborators

Lead sponsor

University of Salamanca

Other

Registry information

Official study title

Effect of Topical Metronidazole in Reducing Periodontal Probing Depth: A Split Mouth Clinical Trial

Acronym: Perio_topic

Important dates

Study start
2018
Primary completion
2022
Study completion
2022
First posted
Feb 20, 2025
Registry last updated
Jul 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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