National Heart Centre Singapore
Singapore, 169609
Active, Not Recruiting
NCT Number: NCT04501562
TO-ChERIsH: Trajectory of Cardiovascular Ageing, Its Determinants and Impact on Health
Specific Aim 1: To determine longitudinal changes in CV ageing (changes in CV imaging) over time.
Hypothesis: There are differences in rates of CV ageing over time.
Specific Aim 2: To study determinants of CV ageing To assess how biological pathways affect CV ageing by studying the relationships between biological signatures measured in longitudinal biospecimens are associated with CV ageing.
Hypothesis: Antecedent biological markers are associated with progression of CV ageing.
Specific Aim 3: To determine the impact of CV ageing progression on the development of clinical CVD and the overall physical, cognitive and functional health of the elderly.
Hypothesis: Those with stable CV imaging phenotypes have lower incidence of clinical CVD and also better overall health in ageing, compared to those with rapid deterioration (unhealthy CV ageing).
Active, Not Recruiting
This study is active but is not currently recruiting participants.
Notify MeKey information
Conditions
Age range
21 year–100 year
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
In Singapore, elderly residents aged 65 years and above make up 10.5% of our population and this is expected to double in 2030 (Singapore Department of Statistics, Ministry of Manpower, Registry of Birth and Deaths, September 2014). Cardiovascular diseases account for the majority of disability-adjusted life years by broad cause group, accounting for 20% of 399,675 life years lost due to mortality and ill-health in 2010 (Source: Estimates from the Singapore Burden of Disease Study 2010).
While chronological ageing is inevitable, a clear understanding is needed as to how ageing becomes a critical risk component of CVD for some individuals, and the mechanisms through which ageing results in such a vulnerable phenotype that leads towards clinical CVD. Following that, clinical tools and clinical guidelines to reduce cardiovascular disease and other health burdens contributed by ageing may be formulated. Such strategies may potentially reduce burdens and cost of healthcare provision to the ageing population.
Our proposal will generate data that identifies functional and structural changes in the cardiovascular system that occur in during ageing. Using a longitudinal design, this research will provide high quality evidence that distinguishes healthy from unhealthy cardiovascular ageing, and reveal determinants and impact of CV ageing over time on CVD and associated health outcomes.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- >= 21 years old
Exclusion criteria
- Unable to provide written informed consent to participate in the study
Treatment and study plan
Examinations
OtherParticipants will undergo focused examinations that include measurement of height, weight, waist circumference, body composition analysis, baseline data collection and blood pressure examinations. Resting electrocardiography will be performed to ascertain sinus rhythm.
Cardiovascular Tests
OtherSpecific quantitative cardiac ageing-related outcome parameters will be examined by multimodal techniques including two-dimensional transthoracic echocardiogram, and/or non-contrast magnetic resonance imaging/magnetic resonance spectroscopy.
Bio-specimen collection
OtherBio-specimens collected will include fresh blood, urine and/or stool specimens.
Clinical/health outcome collection
OtherHealth status will be tracked by telephone follow-up and/or matching at national disease registries at periodic intervals within one to five years, up to three decades.
Primary outcomes
-
To identifies functional and structural changes in the cardiovascular system that occur in during ageing.
Time frame: 5 Years
Health status will be tracked by telephone follow-up and/or matching at national disease registries at periodic intervals within one to five years, up to three decades.
Sponsors and collaborators
Lead sponsor
National Heart Centre Singapore
Other
Registry information
Important dates
- Study start
- 2019
- Primary completion
- 2049
- Study completion
- 2049
- First posted
- Aug 6, 2020
- Registry last updated
- Jun 5, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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