Exercise to Slow Cardiovascular Ageing Progression

In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.

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Key information

Conditions

Cardiac Ageing Behavior Cardiovascular Exercise Motor Activity

Age range

21 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Heart Centre Singapore

Singapore, 169609

Location status: Recruiting

Location contact

Angela Koh, M.D

PRINCIPAL_INVESTIGATOR

Angela Koh, M.D.

CONTACT

[email protected]

67042228

About this study

Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. At the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function.

Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age >=21 years old
Outdoor ambulant

Exclusion criteria

Wheelchair or bed-bound
Dementia
Residing in sheltered or nursing home
Cancer
Participation in ongoing clinical trials that involve interventional drugs or devices
Aneurysms
Acute infections (in the last six months)
Uncontrolled thyrotoxicosis
Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise
Uncontrolled asthma or chronic lung disease
Restrictive lung disease

Treatment and study plan

Primary outcomes

Metabolite profiles

Time frame: 12 Months

To measure changes in serum metabolite levels among participants pre and post exercise intervention.
Cardiovascular structure and function

Time frame: 12 Months

To measure changes in CV structure and function (diastolic function, arterial stiffness) among participants.

Sponsors and collaborators

Lead sponsor

National Heart Centre Singapore

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2026
Study completion: 2050
First posted: Mar 20, 2023
Registry last updated: Jun 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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