To Assess the Effect of Lorcaserin Hydrochloride on Energy Metabolism and Food Intake

Inclusion criteria

• Males or females aged between 18 and 65 years (inclusive)
• Body Mass Index (BMI) is 27.0 to 45.0 kg/m2, inclusive
• Able to give signed informed consent
• Ambulatory and able to perform exercise program (Arena Healthy Lifestyle Program, see Appendix 1)
• Eligible male and female patients must agree not to participate in a conception process
• Considered to be in stable health in the opinion of the Investigator

Exclusion criteria

• Prior participation in any study of lorcaserin.
• Participants who are current smokers or have smoked within the previous 6 months. No smoking will be allowed during the study.
• Clinically significant new illness in the 1 month before screening
• Not suitable to participate in the study in the opinion of the Investigator including an existing physical or mental condition that prevents compliance with the protocol
• Recent history (within 6 months before entering the study) of major depression, anxiety, or other psychiatric disease requiring treatment with prescription medication. SSRI's, SNRI's, and other medications must meet washout requirements.
• Significant dislike or allergy to foods used during the food intake tests
• History of any of the following cardiovascular conditions:

• Myocardial infarction (diagnosed by cardiac enzyme[s] and/or diagnostic ECG), CVA, TIA or RIND within 3 months of screening; cardiac arrhythmia requiring medical or surgical treatment within 3 months of screening
• Unstable angina
• History of congestive heart failure caused by insufficiency, damage, or stenosis of any heart valve
• History of pulmonary artery hypertension
• Positive result of HIV, hepatitis B or hepatitis C screens
• Recent treatment (i.e., within 1 month of the screening visit) with over-the-counter weight loss products or appetite suppressants (including herbal weight loss agents), or within 3 months with a prescription anti-obesity drug (e.g., phentermine, sibutramine, orlistat)
• Participated in any clinical study with an investigational drug, biologic, or device within 1 month prior to screening