Tislelizumab Combined With Chemotherapy and Thoracic Radiotherapy in ES-SCLC

Inclusion criteria

• Patients aged between 18 to 80 years old (inclusive of 18th and 80th birthdays), male or female, at the time of signing the informed consent form;
• Confirmed small cell lung cancer of extensive stage by histology or cytology;
• At least one measurable lesion by imaging studies (according to RECIST 1.1) with a long diameter of ≥10 mm as examined by spiral CT or MRI;
• Within 3 days prior to treatment, an ECOG score of 0 to 1;
• No prior antitumor treatment for extensive stage disease (if the patient has previously received chemotherapy and/or radiotherapy in the limited stage of SCLC, the treatment intent must have been curative, and there must be at least a 6-month treatment-free interval between the end of chemotherapy, radiotherapy, or chemoradiotherapy and the diagnosis of extensive stage SCLC);
• Expected life span of ≥3 months;
• Good function of vital organs;
• The subject voluntarily joins this study, signs the informed consent form, has good compliance, and cooperates with follow-up.

Exclusion criteria

• Concurrent severe respiratory diseases: such as pulmonary fibrosis;
• Presence of psychiatric disorders, hematologic diseases, autoimmune diseases, and severe primary diseases of the heart, brain, liver, or kidneys;
• Uncontrolled active infections;
• Known or suspected allergies to the study medication and its excipients;
• Female patients who are pregnant or breastfeeding, or women of childbearing potential with a positive baseline pregnancy test;
• Prior use of antitumor treatment targeting the PD-(L)1 pathway.