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NCT Number: NCT02190214

Thyroid Disorders in Malaysia: A Nationwide Multicentre Study

This will be a population based study looking at the prevalence of thyroid disorders in Malaysia (including hypo- and hyperthyroidism, subclinical hypo- or hyperthyroidism) and its association with different ethnicity and iodine status. The study will also look at genetic susceptibility for autoimmune thyroid disorders in the Malaysian population

General hypotheses:

The prevalence of thyroid disorders in Malaysia is 10% for hypothyroidism and 2% for hyperthyroidism Hypo- and hyperthyroidism is associated with iodine status in our population There are different susceptibility gene for autoimmune thyroid disorder in different ethnicity in our population

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Key information

Conditions

Hypothyroidism Autoimmune Diseases Disease Attributes Disease Susceptibility Endocrine System Diseases Exophthalmos Eye Diseases Genetic Predisposition to Disease Genetic Susceptibility Goiter Graves Disease Hashimoto Disease Hashimoto's Thyroiditis Hyperthyroidism Immune System Diseases Iodine Deficiency Orbital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Subclinical Hyperthyroidism Subclinical Hypothyroidism Thyroid Diseases Thyroiditis Thyroiditis, Autoimmune

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

This will be a cross-sectional population based study involving Malaysian adults (aged 18 year old and above). Cluster sampling will be used to select respondents that will be representative of the Malaysian population. Selected respondent will be interviewed, anthropometric measurement taken, blood and urine sample taken.

Blood will be analyzed for thyroid function (thyroxine, triiodothyronine and thyroid stimulating hormone), autoantibodies (anti-thyroperoxidase and anti-thyroglobulin). Urine will be analyzed for urinary iodine.

Those diagnosed with autoimmune thyroid disorders with strong family history of thyroid disorders (multiplex multi-generation family involvement) will have their blood sent for whole exome sequencing and linkage analysis done to identify possible susceptible gene for autoimmune thyroid disorders

Respondents detected to have hypo- or hyper- and subclinical hypo- or hyperthyroidism will be referred to their nearest health centre for further evaluation and treatment appropriate for their condition.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged equal or more than 18 years old at the time of sampling
  • Malaysian citizen

Exclusion criteria

  • Respondents who did not give consent

Treatment and study plan

Primary outcomes

  1. Number of participants with abnormal thyroid function

    Time frame: Day 0

    Overt or subclinical hypothyroidism Overt or subclinical hyperthyroidism

Secondary outcomes

  1. Number of participants with positive thyroid autoantibodies

    Time frame: Day 0

    Anti-thyroglobulin Anti-thyroperoxidase

  2. Number of participants with Iodine deficiency status

    Time frame: Day 0

    Urinary iodine level

Other outcomes

  1. Number of participants with genetic susceptibility to autoimmune thyroid disorders

    Time frame: Day 0

    whole exome sequencing and linkage analysis in families with autoimmune thyroid disorders (multiplex multi-generation involvement)

Sponsors and collaborators

Lead sponsor

International Islamic University Malaysia

Other

Collaborators

  • IMU University, Malaysia
  • Malaysian Endocrine and Metabolic Society
  • National University of Malaysia
  • University of Malaya

Registry information

Official study title

Thyroid Disorders in Malaysian: A Nationwide Multicentre Study

Acronym: MyEndo-Thyroid

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Jul 15, 2014
Registry last updated
Oct 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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