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Completed

NCT Number: NCT07688824

The Effect of SPU on Hormonal and Cardiometabolic Factors

The study examines the immediate effect of soleus pushup exercise on cardiometabolic and hormonal functions among hypothyroid patients.

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Key information

Conditions

Hypothyroidism Cardiovascular Diseases Diabete Mellitus Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Healthy Adult Hypertension Hyperthyroidism Metabolic Diseases Nutritional and Metabolic Diseases Thyroid Diseases Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Rehabilitation Sciences

Irbid, Irbid Governorate, 22110, Jordan

About this study

The primary characteristic of hypothyroidism is sluggish metabolism, which is usually associated with abnormal weight gain, lethargy, constipation, heavy menstrual bleeding, hair loss, cold intolerance, and bradycardia. Importantly, these symptoms have been linked to reduced glucose tolerance and insulin sensitivity though glucose turnover and plasma insulin concentration are elevated. These metabolic changes result in hyperlipidemia, hypercholesterolemia, and elevated insulin resistance, and circulatory low-density lipoprotein cholesterol and total triglyceride levels. Hormonal replacement therapy, the primary treatment for hypothyroidism, partially restores the thyroid function and tappers down the disease symptoms. However, the therapy is associated a plethora of side effects, thus alternative therapies are warranted.

The effect of exercise on thyroid function and metabolism among patients with hypothyroidism is still equivocal. The soleus pushup exercise, a localized exercise that stimulates mainly oxidative metabolism, has been shown to have promising, favorable changes in systemic metabolism. Therefore, the current study compares metabolic and hormonal responses to soleus pushup exercise in patients with hypothyroidism versus healthy controls.

Patients diagnosed with hypothyroidism are recruited to participate in the study. Cardiovascular and circulatory, metabolic, and hormonal measures are determined from blood samples obtained from the patients. Age- and gender-matched healthy individuals are recruited to serve as controls.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Individuals aged 18-80,
  • Patients diagnosed with hypothyroidism
  • Patients diagnosed with hyperthyroidism
  • Patients diagnosed with hypertension
  • Patients diagnosed with diabetes mellitus
  • Prediabetics
  • Individuals who usually avoid regular physical/muscular activities involving lower limbs
  • Age/gender matched apparently healthy individuals

Exclusion criteria

  • Patients diagnosed with orthopedic diseases
  • Patients diagnosed with cardiovascular diseases (other than hypertension)
  • Patients diagnosed with renal dysfunction

Treatment and study plan

Soleus pushup exercise

Behavioral

The participants are given the soleus push-up exercise

Primary outcomes

  1. Total cholesterol

    Time frame: 3 hours

    Total cholesterol will be measured in blood and reported in mg/dL.

  2. Triglycerides

    Time frame: 3 hours

    Triglycerides will be measured in blood and reported in mg/dL.

  3. HDL-C

    Time frame: 3 hours

    High-density lipoprotein cholesterol will be measured in blood and reported in mg/dL.

  4. LDL-C

    Time frame: 3 hours

    Low-density lipoprotein cholesterol will be calculated using the lipid profile and reported in mg/dL.

  5. VLDL-C

    Time frame: 3 hours

    Very-low-density lipoprotein cholesterol will be calculated from triglycerides and reported in mg/dL.

  6. Non-HDL cholesterol

    Time frame: 3 hours

    Non-HDL cholesterol will be calculated as total cholesterol minus HDL-C and reported in mg/dL.

  7. Apolipoprotein A-I

    Time frame: 3 hours

    Apolipoprotein A-I will be measured in blood and reported in mg/dL.

  8. Apolipoprotein B

    Time frame: 3 hours

    Apolipoprotein B will be measured in blood and reported in mg/dL.

  9. Lipoprotein(a)

    Time frame: 3 hours

    Lipoprotein(a) will be measured in blood and reported in mg/dL or nmol/L, depending on the laboratory assay.

  10. Fasting blood glucose

    Time frame: 3 hours

    Fasting blood glucose will be measured in blood and reported in mg/dL.

  11. Random blood glucose

    Time frame: 3 hours

    Random blood glucose will be measured in blood and reported in mg/dL.

  12. HbA1c

    Time frame: 3 hours

    Glycated hemoglobin will be measured in blood and reported as a percentage.

  13. Insulin

    Time frame: 3 hours

    Insulin will be measured in blood and reported in µIU/mL or mIU/L, depending on the laboratory assay.

  14. Glucagon

    Time frame: 3 hours

    Glucagon will be measured in blood and reported in pg/mL.

  15. Catecholamines

    Time frame: 3 hours

    Catecholamines will be measured in blood and reported in pg/mL.

  16. Thyroid-stimulating hormone

    Time frame: 3 hours

    Thyroid-stimulating hormone will be measured in blood and reported in mIU/L or µIU/mL, depending on the laboratory assay.

  17. Triiodothyronine

    Time frame: 3 hours

    Triiodothyronine will be measured in blood and reported in ng/dL.

  18. Thyroxine

    Time frame: 3 hours

    Thyroxine will be measured in blood and reported in µg/dL.

  19. Brain-derived neurotrophic factor

    Time frame: 3 hours

    Brain-derived neurotrophic factor will be measured in blood and reported in pg/mL or ng/mL, depending on the laboratory assay.

  20. Leptin

    Time frame: 3 hours

    Leptin will be measured in blood and reported in ng/mL.

  21. Adiponectin

    Time frame: 3 hours

    Adiponectin will be measured in blood and reported in µg/mL.

  22. Glucagon-like peptide

    Time frame: 3 hours

    Glucagon-like peptide will be measured in blood and reported in pmol/L or pg/mL, depending on the laboratory assay.

  23. Heart rate

    Time frame: 3 hours

    Heart rate will be measured using the standard auscultatory method and reported in beats per minute.

  24. Systolic blood pressure

    Time frame: 3 hours

    Systolic blood pressure will be measured using the standard auscultatory method and reported in mmHg.

  25. Diastolic blood pressure

    Time frame: 3 hours

    Diastolic blood pressure will be measured using the standard auscultatory method and reported in mmHg.

  26. Pulse pressure

    Time frame: 3 hours

    Pulse pressure will be calculated as systolic blood pressure minus diastolic blood pressure and reported in mmHg.

  27. Rate-pressure product

    Time frame: 3 hours

    Rate-pressure product will be calculated as heart rate multiplied by systolic blood pressure and reported in bpm × mmHg.

  28. Mean arterial pressure

    Time frame: 3 hours

    Mean arterial pressure will be calculated as diastolic blood pressure plus one-third of pulse pressure and reported in mmHg.

Sponsors and collaborators

Lead sponsor

King Abdullah University Hospital

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 7, 2026
Registry last updated
Jul 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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