Thyroid Cancer in Surgical Treated Multinodular Goiter

This study aims to investigate, based on existing knowledge, the incidence of occult thyroid carcinoma in a cohort of patients with MNG, providing new insights into the prevalence and characteristics of thyroid malignancies in MNG. It seeks to contribute to optimizing diagnostic evaluations for patients with multinodular goiter.

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Key information

Conditions

Goiter, Nodular Endocrine Gland Neoplasms Endocrine System Diseases Goiter Head and Neck Neoplasms Neoplasms Neoplasms by Site Thyroid Cancer Thyroid Diseases Thyroid Neoplasms Total Thyroidectomy

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Foggia

Foggia, FG, 71122, Italy

About this study

This retrospective study included patients with a preoperative diagnosis of multinodular goiter who underwent total or partial thyroidectomy from January 2018 to May 2024 at the Department of Medical and Surgical Sciences at the University Hospital "Ospedali Riuniti" in Foggia. The study's objective was to investigate the incidence of thyroid carcinoma in patients undergoing thyroidectomy for MNG, also analyzing associated demographic and clinical variables.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients diagnosed with multinodular goiter via thyroid ultrasound, with or without FNA cytology.
patients who underwent surgery.
availability of complete clinical data

Exclusion criteria

history of thyroid carcinoma or other thyroid neoplasms.
not completed postoperative follow up.
patients with preoperative FNA results indicating malignancy (TIR 4-5), suspicion of malignancy (TIR 3), or indeterminate significance (TIR 1)

Treatment and study plan

total or partial thyroidectomy

Procedure

Total thyroidectomy is a surgical procedure that involves the complete removal of the thyroid gland. It is performed to treat conditions such as thyroid cancer, large goiters, or severe hyperthyroidism. The surgery is typically conducted under general anesthesia through an incision in the lower neck. Postoperative management may include hormone replacement therapy with levothyroxine to compensate for the loss of thyroid function. Potential complications include hypocalcemia due to parathyroid gland injury and vocal cord dysfunction from recurrent laryngeal nerve damage.

Primary outcomes

incidence of occult thyroid carcinoma

Time frame: 6 years

Incidence of occult thyroid carcinoma in a cohort of patients with multinodular goiter, providing new insights into the prevalence and characteristics of thyroid malignancies.

Sponsors and collaborators

Lead sponsor

University of Foggia

Other

Registry information

Official study title

Thyroid Cancer in Surgically Treated Multinodular Goiter: Incidence and Histopatological Outcomes

Important dates

Study start: 2018
Primary completion: 2024
Study completion: 2024
First posted: Apr 11, 2025
Registry last updated: Apr 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed