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OpenTrials
Completed

NCT Number: NCT06826495

Thiol Disulfide Balance and Oxidative Stress Change in Endometrial Polyp Patients

Changes in Thiol Disulfide Balance and Oxidative Stress Mechanisms in Patients with Endometrial Polyps

Completed

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Key information

Conditions

Endometrial Polyp Oxidative Stress

Age range

20 year–48 year

Sex eligibility

Female

Study type

Observational

Primary location

Alanya Training and Research Hospital Gynecology and Obstetrics Department

Antalya, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For participants in the control group:

  • To be without endometrial polyp

For the polyp group, they were as follows:

  • Individuals experiencing menometrorrhagia
  • A body mass index (BMI) of 25 or more
  • Hypertension
  • Endometrial polyps detected via saline infusion ultrasonography

Exclusion criteria

  • Pregnancy
  • Diabetes mellitus
  • Pelvic mass
  • Malignancy
  • The use of Tamoxifen, hormonal contraceptives, or hormone replacement therapy.

Treatment and study plan

Primary outcomes

  1. Oxidative stress markers

    Time frame: From January 2021 to January 2022

    Total antioxidant status (μmol Trolox equivalent/ L)

  2. Oxidative stress markers

    Time frame: From January 2021 to January 2022

    Total oxidant status (μmol H2O2 equivalent/L)

  3. Oxidative stress markers

    Time frame: From January 2021 to January 2022

    Oxidative stress index (arbitrary unit)

  4. Oxidative stress markers

    Time frame: From January 2021 to January 2022

    Paraoxonase (U/L)

  5. Oxidative stress markers

    Time frame: From January 2021 to January 2022

    Arylesterase (Ku/l)

  6. Oxidative stress markers

    Time frame: From January 2021 to January 2022

    Total thiol (µmol / L)

  7. Oxidative stress markers

    Time frame: From January 2021 to January 2022

    Native thiol (µmol / L) / alb (g / l)

  8. Oxidative stress markers

    Time frame: From January 2021 to January 2022

    Disulfide (-S-S-) (µmol / L) / alb (g/l)

  9. Oxidative stress markers

    Time frame: From January 2021 to January 2022

    Ischemia-modified albumin (u/L)

Sponsors and collaborators

Lead sponsor

Mardin Artuklu University

Other

Registry information

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Feb 14, 2025
Registry last updated
Feb 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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