The Use of Nomegestrol Acetate/Estradiol in Random Start Rapid Endometrial Preparation

The presence of a thin endometrium plays an important role in enabling the best conditions for hysteroscopic surgery. Recently, for this purpose, many studies have evaluated the effect of preoperative administration of a variety of drugs. We explored the efficacy of random started 14-day administration of Nomegestrol Acetate/Estradiol, in rapid preparation of endometrium for hysteroscopic polypectomy.

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Key information

Conditions

Endometrial Polyp Endometrial Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Urogenital Diseases Uterine Diseases

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Andrea Etrusco, Palermo, Italy

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with endometrial polyps.

Exclusion criteria

Patients with other endometrial pathologies.

Treatment and study plan

Nomegestrol Acetate/Estradiol 2.5mg/1.5mg

Drug

hysteroscopic polipectomy after starting 14-day treatment with oral Nomegestrol Acetate/Estradiol 2.5mg/1.5mg at any time of the menstrual cycle

Primary outcomes

Quality of endometrial preparation

Time frame: 14th day of treatment

Quality of endometrial preparation assessed visually intraoperatively by the surgeon using a visual analog scale from 0 to 5.

Sponsors and collaborators

Lead sponsor

University of Palermo

Other

Collaborators

University of Roma La Sapienza

Registry information

Official study title

The Use of Nomegestrol Acetate/Estradiol in Random Start Rapid Preparation of Endometrium Before Office Hysteroscopic Polypectomies: a Multicenter, Prospective, Randomized Study

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2024
First posted: Mar 18, 2024
Registry last updated: Apr 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed