Skip to main content
OpenTrials
Completed

NCT Number: NCT00052091

Therapy for Depressed Elders With Thought Problems

This study will compare the effectiveness of Problem Solving Therapy and Brief Supportive Therapy in treating elderly patients with major depression and thought problems.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Depression Behavior Behavioral Symptoms Cognition Disorders Mental Disorders Neurocognitive Disorders

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

University of California at San Francisco, San Francisco, California, United States

Loading trial locations.

About this study

Patients who suffer from a combination of major depression and executive dysfunction symptoms often respond poorly to treatment with antidepressants. It is important, therefore, to find effective alternative therapies to treat these symptoms.

Patients are randomly assigned to receive 12 sessions (1 session/week for 12 weeks) of either PST or BST. Following treatment, patients are followed for 6 months to determine functional and clinical outcomes. Depression scales, disability scales, and scales that measure problem solving skills are used to assess patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Nonpsychotic, unipolar major depression
  • Cognitive impairment
  • English speaking

Exclusion criteria

  • High suicide risk
  • Dementia
  • Acute or severe medical illness
  • Current psychotherapy

Treatment and study plan

Problem solving therapy

Behavioral

A 12 week cognitive behavioral intervention for depression that teaches patients a structured approach to solving social problems.

Brief Supportive Therapy

Behavioral

A 12 week intervention for depression that focuses on supporting patients attempts to cope with depression.

Primary outcomes

  1. Hamilton Rating Scale for Depression

    Time frame: Measured at screening, weeks 1 through 12, and week 36

Sponsors and collaborators

Lead sponsor

University of Washington

Other

Collaborators

  • National Institute of Mental Health (NIMH)

Registry information

Official study title

PST in Geriatric Depression With Executive Dysfunction

Important dates

Study start
2002
Primary completion
2008
Study completion
2008
First posted
Jan 23, 2003
Registry last updated
Jan 29, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.