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NCT Number: NCT07737080

The Villainous Vape: Advancing Vaping Prevention Among Adolescents Through a Comic Book

This is a randomized controlled trial to assess the feasibility, acceptability, and preliminary impact of The Villainous Vape, a vaping prevention comic book, among adolescents.

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Key information

Conditions

Vaping Behaviors

Age range

12 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Rochester Medical Center

Rochester, New York, 14642, United States

Location contact

Francisco Cartujano, MD

CONTACT

[email protected]

585-353-0035

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Know how to read and speak English and/or Spanish
  • Be at least 12 but no greater than 17 years old
  • Be willing to complete three study visits over Zoom or a phone call
  • Live in Orleans County, New York

Exclusion criteria

  • A household member participating in the study
  • Living outside of Orleans County, New York

Treatment and study plan

Health Impacts of E-cigarettes

Behavioral

Health Impacts of E-cigarettes is a one-page educational flyer that outlines the impact of using electronic cigarettes and what is being done to mitigate youth vaping. The flyer reviews the dangers of nicotine delivery devices, lung damage, and how to stay safe in the event of social exposure to vaping. Health Impacts of E-cigarettes was developed by the U.S. Food and Drug Administration.

Mind Matters: The Body's Response to Nicotine, Tobacco, and Vaping

Behavioral

Mind Matters: The Body's Response to Nicotine, Tobacco, and Vaping is a five-page educational brochure that utilizes an illustrative approach to sharing basic information about nicotine and tobacco products. The brochure focuses on the physiological effect of these products, health effects, addiction, and key statistics. Mind Matters: The Body's Response to Nicotine, Tobacco, and Vaping was developed by the U.S. National Institute on Drug Abuse.

The Villainous Vape

Behavioral

The Villainous Vape is an eleven-page comic book that follows Daniel, a high school student who gets addicted to vaping and is hospitalized in the intensive care unit because he develops a lung disease. Support from friends and family helps Daniel make the decision to quit vaping. Throughout the comic, readers are exposed to various vaping-related facts and statistics.

Primary outcomes

  1. Percentage Of Participants Who Complete the Month 3 Assessment.

    Time frame: Month 3

    The percentage will be calculated as the number of participants who complete the Month 3 assessment divided by the total number of enrolled participants.

  2. Percentage Of Participants Who Are Satisfied With Their Assigned Intervention at Month 3

    Time frame: Month 3

    All participants will be asked the following question at Month 3: "How satisfied are you with the assigned intervention?" Responses will be collected using a 5-item Likert scale. The percentage of participants who are satisfied with their assigned intervention at Month 3 will be calculated as the number of participants who respond "satisfied" or "extremely satisfied," divided by the total number of participants in each group.

  3. Percentage Of Participants With Reduced Susceptibility To Future Vaping

    Time frame: Baseline to Month 3

    Susceptibility to future vaping will be assessed using the susceptibility to e-cigarettes scale. The scale consists of three questions: 1) Have you ever been curious about using e-cigarettes? 2) Do you think you will use e-cigarettes in the next year? 3) If one of your best friends were to offer you an e-cigarette, would you use it? The questions use a 4-point Likert scale ranging from not at all curious (1) to very curious (4) for question one and definitely not (1) to definitely yes (4) for questions two and three. Participants who provide a response other than "not all curious" or "definitely not" will be considered "susceptible". The percentage will be calculated as the number of participants who demonstrate a change from "susceptible" at baseline to "not susceptible" at Month 3, divided by the total number of participants in each group.

Study contacts

Contact information is provided by the study sponsor or research team.

Francisco Cartujano, MD

CONTACT

[email protected]

(585) 273-1646

Sponsors and collaborators

Lead sponsor

University of Rochester

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 30, 2026
Registry last updated
Jul 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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