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NCT Number: NCT06809309

The Ventilation During In-hospital Cardiac Arrest Study

The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.

The main questions it aims to answer are:

What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?

Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.

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Key information

Conditions

Cardiac Arrest (CA) Cardiovascular Diseases Heart Arrest Heart Diseases In-hospital Cardiac Arrest Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital of Southern Jutland - Aabenraa, Aabenraa, Denmark

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • In-hospital cardiac arrest
  • Age ≥ 18 years
  • >1minute of recorded ventilation data

Exclusion criteria

  • Documented do-not-attempt cardiopulmonary resuscitation order
  • Invasive mechanical circulatory support at the time of the cardiac arrest

Treatment and study plan

Positive pressure ventilation during cardiopulmonary resuscitation

Other

The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation.

Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.

Other names: manual ventilation, artificial ventilation, intra-arrest ventilation, bag-valve-mask ventilation, invasive ventilation

Primary outcomes

  1. Fraction of patients with return of spontaneous circulation (ROSC)

    Time frame: ROSC is assessed immediately following cardiopulmonary resuscitation.

    ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes.

Secondary outcomes

  1. Fraction of patients surviving until day 30

    Time frame: Assessed at day 30 after cardiac arrest.

    Patient survival for at least 30 days following cardiac arrest.

Other outcomes

  1. Fraction of patients with pulmonary complications

    Time frame: From date of ROSC until date of intensive care unit discharge or date of death from any cause, whichever came first, assessed up to 30 days.

    Composite endpoint of pulmonary complications after return of spontaneous circulation (ROSC) including acute respiratory distress syndrome (ARDS), aspiration, pneumothorax and hemothorax.

  2. Number of days alive without mechanical ventilation

    Time frame: From date of ROSC until day 30 or date of death from any cause, whichever came first.

    Days patients are alive without receiving mechanical ventilation after return of spontaneous circulation (ROSC).

  3. Number of days alive outside the intensive care unit

    Time frame: From date of ROSC until day 90 or date of death from any cause, whichever came first.

    Days patients are alive outside of the intensive care unit after return of spontaneous circulation (ROSC).

Study contacts

Contact information is provided by the study sponsor or research team.

Johannes Wittig, MD

CONTACT

[email protected]

+45 78 42 00 00

Kasper G Lauridsen, MD, PhD

CONTACT

[email protected]

+45 78 42 00 00

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

The Ventilation During In-Hospital Cardiac Arrest (VENT-IHCA) Study

Acronym: VENT-IHCA

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Feb 5, 2025
Registry last updated
Mar 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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