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NCT Number: NCT05558527

The Social Regulation of Threat-related Vigilance and Arousal

This study will examine the effects of social support on threat vigilance and arousal using eye tracking. We will also test the moderating effects of trauma and discrimination history.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Nevada, Reno

Reno, Nevada, 89557, United States

Location status: Recruiting

Location contact

Cynthia L Lancaster, PhD

CONTACT

About this study

Both interpersonal trauma (IPT) and ethno-racial discrimination amplify risk for hyper-arousal symptoms of posttraumatic stress disorder (PTSD), but the mechanism of this effect is unclear. Prior research suggests that social support plays an important role in regulating emotional responses, a process called social emotion regulation. This study will test whether a history of IPT and/or ethno-racial discrimination influence the social regulation of arousal and vigilance. Social regulation will be tested by contrasting responses under conditions with and without social support.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • In a stable romantic relationship for 6 months or more
  • Normal vision or corrected-to-normal vision
  • Fluent in English

Exclusion criteria

  • If vision is corrected-to-normal, needs to use hard contact lenses, bifocal contact lenses, or glasses
  • Experienced a traumatic event within the past 4 weeks

Treatment and study plan

Social Support

Behavioral

social support is provided in the form of social touch (hand holding)

Primary outcomes

  1. Vigilance Related Eye Movements - Number of Eye Fixations

    Time frame: Collected from minute 15 to minute 45 of study participation, approximately

    Participants will view 15 pictures of natural environmental scenes for 10 seconds per image. We will use an eye tracker to examine the number of eye fixations per scene. A greater number of fixations during the 10 second presentation of a scene would indicate greater vigilance.

  2. Vigilance Related Eye Movements - Visual Scanning

    Time frame: Collected from minute 15 to minute 45 of study participation, approximately

    Participants will view 15 pictures of natural environmental scenes for 10 seconds per image. We will use an eye tracker to examine the proportion of the scene that they look at (fixate on) out of approximately 80 possible sectors. A greater proportion of the scene they fixate on would indicate greater vigilance.

  3. Threat-Related Physiological Arousal - Pupil Dilation

    Time frame: Collected from minute 45 to minute 75 of study participation, approximately

    Participants will view a series of visual cues (either an 'X' or an 'O') where an 'X' signals a possible (20% probability) aversive auditory stimulus (human scream). We will examine pupil dilation during the task in order to measure arousal in response to uncertain threat. We will calculate average pupil dilation during the wait period after threat cues (X) and after safety cues (O). We will subtract average pupil dilation after safety cues from threat cues to create an index of threat-related arousal. Greater pupil dilation (for threat minus safety cues) would indicate greater threat-related arousal.

Study contacts

Contact information is provided by the study sponsor or research team.

Cynthia L Lancaster, PhD

CONTACT

[email protected]

(775) 682-8145

Kylie Baer, MS

CONTACT

[email protected]

(775) 682-8145

Sponsors and collaborators

Lead sponsor

University of Nevada, Reno

Other

Registry information

Official study title

Effects of Trauma and Discrimination on the Social Regulation of Threat-related Vigilance and Arousal

Important dates

Study start
2025
Primary completion
2028
Study completion
2029
First posted
Sep 28, 2022
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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