The Relationship Between Serum Gasdermin-D Levels and Pyroptosis and Preterm Labor

This prospective case- control study was conducted between 15 July 2021 and 15 July 2022 at Bursa Yüksek İhtisas Training and Research Hospital. The study was conducted with pregnant women between the ages of 18-45 who were idiopathic preterm labor. Pregnant women between the ages of 18-45 who were diagnosed with preterm labor between 24-37 weeks of gestational were included. This study was conducted with 160 pregnant women who were diagnosed with idiopathic preterm labor and 167 healthy pregnant women who were in the same gestational week as these pregnant women and were not diagnosed with preterm labor. Group 1 patients diagnosed with preterm labor between 24-37 weeks( study group) (n:160), Group 2 consisted of healthy pregnant women who were not diagnosed with preterm labor between 24-37 weeks ( control group) (n: 167) . In group 1, 80 patients were diagnosed with early preterm (between 24-34 weeks ) and 80 patients with late preterm labor (34-36+6 weeks).

Inclusion criteria

• Pregnant women who were diagnosed with idiopathic preterm labor and gave birth in our hospital
• Pregnant women without vaginal infection
• Healthy pregnant women between 24-37 weeks without a diagnosis of preterm labor

Exclusion criteria

• Multiple pregnancies
• Pregnant women with a prediagnosis of chromosomal and congenital anomalies in the fetus
• Women with a known infective or autoimmune disease before pregnancy