Uterine Artery Doppler Indices and Uterocervical Angle Measurment in Prediction of Preterm Labor

In this study the aim is to evaluate the combined predictive value of both uterine artery doppler and uterocervical angle measurement in a prospective cohort study design to predict preterm labor . The abnormal mid-trimester uterine artery resistance, pulsatility index and diastolic notching measured with Doppler sonography is known to be predictive for preeclampsia and, hence, for iatrogenic Preterm labor. It will be measured via trans abdominal approach.

The measurement of UCA in the second trimester of pregnancy is strongly associated with the occurrence of spontaneous Preterm labor and will be measured via transvaginal approach .

Both measurement will be conducted between 24 to 34 weeks gestational .

Inclusion criteria

• Patient who will give verbal & written will informed consent.
• Pregnant women between 18 and 40 years old of age
• Singleton pregnancy
• Gestational age will be confirmed by first trimester ultrasound scan (<14 weeks).
• Gestational age between 24 and 34 weeks .
• Threatened preterm labor which is defined as:

Presence of at least one uterine contraction every 10 minutes lasting ≥30 seconds . Cervical dilatation ≤3 cm . Cervical effacement <80%.

Exclusion criteria

Obstetric:

• Ruptured membranes
• Clinical evidence of Chorioamnionitis.
• Fetal compromise on evaluation.
• Severe obstetric complications (e.g., severe Preeclampsia, Eclampsia).
• Diagnosed intrauterine growth restriction (IUGR).
• Congenital fetal anomalies.
• Multiple pregnancies.
• Prior cervical surgery (e.g., cone biopsy, cerclage).

Non-Obstetric:

• Significant maternal medical disorders (e.g., chronic hypertension, diabetes mellitus, liver dysfunction).
• Severe non-obstetric complications (e.g., acute abdomen).