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Completed

NCT Number: NCT06967779

The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery

This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury induced by cardio-pulmonary by-pass and its association with genetic predisposition in patients undergoing coronary artery bypass grafting (CABG) carrying BDNF gene polymorphism (Val66Met).

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Key information

Conditions

Delirium - Postoperative BDNF CABG Confusion Delirium Emergence Delirium Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Uniwersytecki Szpital Kliniczny nr 2 PUM w Szczecinie

Szczecin, West Pomeranian Voivodeship, 70-111, Poland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

include:

  • Age > 18 years.
  • Planned coronary artery bypass grafting (CABG) procedure with the use of cardiopulmonary by-pass (CPB).
  • Ability to understand and sign an informed consent form.

Exclusion criteria

include:

  • Emergency surgery.
  • Previous known cognitive disorders: Mini Mental State Examination (MMSE) score <15.
  • Baseline delirium (positive CAM test prior to surgery).
  • Diagnosis of psychiatric syndromes in the past - i.e. depression, dementia, psychosis or schizophrenia.
  • Inability to understand Polish language.
  • Inability to give and sign informed consent due to auditory or visual dysfunction.

Treatment and study plan

Primary outcomes

  1. The main aim of the study will be to assess the correlation between brain function disorders, defined as abnormal BDNF levels, and postoperative delirium.

    Time frame: Up to a year after the procedure.

Sponsors and collaborators

Lead sponsor

Pomeranian Medical University Szczecin

Other

Registry information

Official study title

Analysis of the Relationship Between the Concentration of the Brain Derived Neurotrophic Factor (BDNF) in Plasma, the Occurrence of BDNF Gene Polymorphism (Val66Met) and White Blood Cell Markers and the Incidence of Postoperative Central Nervous System Disorders in Patients Undergoing General Anesthesia for Cardiac Surgery With Extracorporeal Circulation

Important dates

Study start
2021
Primary completion
2023
Study completion
2024
First posted
May 13, 2025
Registry last updated
May 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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