Skip to main content
OpenTrials
Completed

NCT Number: NCT07673510

Perioperative Antibiotic Exposure and Postoperative Delirium in Older Adults Undergoing Elective Non-cardiac Surgery: A Single-center Prospective Cohort Study

This study aimed to characterize the current patterns of perioperative prophylactic antibiotic use and to systematically evaluate the association between different antibiotic classes and the occurrence of POD, thereby providing clinically relevant safety evidence for perioperative antibiotic decision-making and delirium prevention strategies.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Delirium - Postoperative Confusion Delirium Emergence Delirium Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chinese PLA General Hospital, Beijing

Beijing, China

About this study

This prospective, observational, single-center cohort analysis was a substudy of the Perioperative Database of Chinese Elderly Patients (PDCEP) study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients over 65 years old
  • patients undergoing elective non-cardiac surgery

Exclusion criteria

  • older adult patients who had history of psychotic disorders
  • history of neurological disease
  • conditions that would make assessments for delirium unreliable
  • preoperative infection
  • severe hepatic and renal dysfunction, minor and intermediate clean-incision surgery
  • missing data exceeding 5%, and no medication records

Treatment and study plan

Perioperative antibiotics exposure

Drug

Antimicrobial exposure was defined as a record of antibiotic use prior to the occurrence of delirium. Antimicrobials were divided into five non-mutually exclusive groups: beta-lactams (subclasses: first- through fourth-generation cephalosporins, penicillins and carbapenems), nitroimidazoles, glycopeptides, fluoroquinolones, and others (subclasses: aminoglycosides, oxazolidinones, antifungals, lincosamides, macrolides, and fosfomycins).

Primary outcomes

  1. Incidence of postoperative delirium

    Time frame: Participants will be followed for the duration of hospital stay, an expected average of 7 days.

    Evaluations are conducted twice a day.

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Important dates

Study start
2020
Primary completion
2022
Study completion
2026
First posted
Jun 29, 2026
Registry last updated
Jun 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.