The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy

The purpose of this study is to gain further insights into the molecular pathogenesis of Fuchs' endothelial corneal dystrophy (FECD), to identify targets for potential specific drug therapy.

Completed

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Key information

Conditions

Fuchs' Endothelial Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities Corneal Diseases Corneal Dystrophies, Hereditary Eye Diseases Eye Diseases, Hereditary Genetic Diseases, Inborn

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Translational Cell and Tissue Research - campus Sint-Raf - UZ Leuven

Leuven, 3000, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

FECD
normal corneas (including enucleations for uveal melanoma)
non-FECD oedematous corneas

Exclusion criteria

prior irradiation therapy for uveal melanoma
corneal extension of uveal melanoma

Treatment and study plan

No intervention

Other

Primary outcomes

cytokine levels

Time frame: at time of prelevation (once, no intervention)

dosage of cytokine levels in aqueous humour (exploratory, non-interventional study)
gene expression levels

Time frame: at time of prelevation (once, no intervention)

microarray expression analysis, reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR), RNA-sequencing (exploratory, non-interventional study)
protein content

Time frame: at time of prelevation (once, no intervention)

immunohistochemistry and immunofluorescence

Sponsors and collaborators

Lead sponsor

Universitaire Ziekenhuizen KU Leuven

Other

Collaborators

Fund for Scientific Research, Flanders, Belgium
Funds for Research in Ophthalmology, Belgium
Mieke Perdaens fund for Eye Research

Registry information

Important dates

Study start: 2012
Primary completion: 2017
Study completion: 2017
First posted: Feb 20, 2013
Registry last updated: May 24, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed