The Migraine and Pain Study GeneBank at Scripps Clinic Registry (MAPS)

It is estimated that over one-third of the world's population suffers from persistent or recurrent pain. Migraine is highly heritable and the majority of juveniles who suffer from the disorder have a mother or father who also have the disease. The blood or saliva samples will go through DNA analysis and be sequenced for candidate genes or subjected to whole-genome sequencing. By creating a MAPS GeneBank from these patients' blood/saliva donations we will ultimately be able to define genes for migraine and pain diseases.

Inclusion criteria

• Family members (genetic duo or trio), consisting of an adolescent 10 to 18 years of age and at least one of their biologic parents willing to be participate in trial
• Adolescent and at least 1 biologic parent with Migraine diagnosis confirmed by Dr. Christy Jackson
• Is reliable, cooperative and willing to comply with all protocol-specified procedures and/or sub-study if consented
• Able to understand and grant informed consent

Exclusion criteria

• Patient has been previously enrolled in the MAP GeneBank at Scripps Clinic Registry
• Has a significant chronic medical condition (i.e.chronic meningitis or a secondary origin/cause of headache) which, in the investigator's option, may interfere with the patient's optimal participation in the study
• Treatment with any investigational agents or devices within 30 days preceding enrollment in the study
• Has undergone ECT within 90 days preceding enrollment in the study