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Active, Not Recruiting

NCT Number: NCT01623076

The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders

This study seeks to determine the biologic causes of inflammation in patients with Transverse Myelitis (TM) Neuromyelitis Optica Spectrum Disorder (NMOSD) and related conditions. While patients will be treated according to decisions with their treating physician, this study will collect data and samples from patients prospectively to gain a better understanding of the disease. We are seeking to understand why some patients respond to medications, while others do not. We also seek to understand what happens biologically, preceding relapses. Gathering these data and samples will allow researchers to identify new ways of diagnosing and treating these diseases. Data and samples will be shared with researchers around the world to support collaborative efforts to treat these conditions.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Neuromyelitis Optica Autoimmune Diseases Autoimmune Diseases of the Nervous System Central Nervous System Diseases Central Nervous System Infections Cranial Nerve Diseases Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Eye Diseases Immune System Diseases Infections Myelitis Myelitis, Transverse Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms Neurodegenerative Diseases Neuroinflammatory Diseases Neuromyelitis Optica Spectrum Disorder Optic Nerve Diseases Optic Neuritis Paraneoplastic Syndromes Paraneoplastic Syndromes, Nervous System Spinal Cord Diseases Transverse Myelitis

Age range

6 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States

About this study

This study seeks to determine the biologic causes of inflammation in patients with Neuromyelitis Optica (NMO), Transverse Myelitis (TM), optic neuritis (ON), related conditions and healthy controls. While patients will be treated according to decisions with their treating physician, this study will collect data and samples from patients prospectively to gain a better understanding of the disease. We are seeking to understand why some patients respond to medications, while others do not. We also seek to understand what happens biologically, preceding relapses. Gathering these data and samples will allow researchers to identify new ways of diagnosing and treating these diseases. Data and samples will be shared with researchers around the world to support collaborative efforts to treat these conditions.

Patients will agree to share medical records, complete questionnaires and donate samples on a timed basis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 6 years or greater
  • Male or Female
  • Patient or Parent (in the case of a minor) able to give informed consent
  • For patients 10 to 17, patient able to assent
  • Patient diagnosed with NMO, NMOSD, TM or ON

Exclusion criteria

  • Unable to maintain scheduled visits
  • Patient has known HIV or hepatitis C infection

Treatment and study plan

Primary outcomes

  1. Measure change in standard clinical assessments over time

    Time frame: Every study visit

    Standard clinical assessments include: relapse information, level of disability based on EDSS score, high and low contract visual acuity, ambulation index, optical coherence tomography, and MRI, and neurologic/physical exam

Secondary outcomes

  1. Measure change in cognition measures over time

    Time frame: Every study visit

    Cognition measures include the SDMT, JLO, and PASAT

  2. Measure change in self-reported quality of life surveys

    Time frame: Every study visit

    Surveys include MSNQ, MSQOL-54, QIDS, BDI-II, FSS, ESS, MFIS, BPI, and Neuro-QoL

  3. B cell population changes

    Time frame: Up to 5 years

    Measure B cell subtypes and changes over time

Sponsors and collaborators

Lead sponsor

University of Texas Southwestern Medical Center

Other

Registry information

Official study title

Collaboration on Neuroimmunology: Question, Understand, Educate, Restore - The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders

Important dates

Study start
2012
Primary completion
2030
Study completion
2030
First posted
Jun 19, 2012
Registry last updated
Jan 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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