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Completed

NCT Number: NCT01819337

The Influence of Preoperative Cardiopulmonary Capacity on the Perioperative Lactate Level

The aim of this study is to identify if there exists a correlation between the preoperative cardiopulmonary capacity - measured in MET's - and the perioperative lactate serum level.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Helios Klinikum Wuppertal

Wuppertal, North Rhine-Westphalia, 42283, Germany

About this study

The determination of the cardiopulmonary (c/p) capacity is very important for the evaluation of every patient undergoing surgery. The ability to climb at least two flight of stairs is seen to be an acceptable c/p capacity for surgery. There are several ways to evaluate the fitness of patients. A common method to estimate the cardiopulmonary capacity is defining patients through the MET's (metabolic equivalents) scale. MET's can be defined relatively easy through a simple questionnaire. Patients with a reduced c/p capacity have less than 4 MET's, patients with a relatively good c/p capacity have 4-10 MET's and patients with a excellent c/p capacity have more than 10 MET's.

The lactate level in blood serum is a common parameter to asses anaerobic metabolism in patients. A high lactate level correlates with higher mortality rates and outcome.

To yet it is not clear if there exists a correlation between the preoperative cardiopulmonary capacity measured in MET's and the perioperative lactate level. We hypothysed that patients with a reduced cardiopulmonary capacity are associated with higher perioperative lactate levels, as these group of patients compensate the stressors operation/anesthesia less than patients with a good c/p capacity.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 18 years

Exclusion criteria

  • Cardiac surgery

Treatment and study plan

Primary outcomes

  1. lactate - venous blood gas analysis

    Time frame: venous lactate will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours

    mmol/l

Secondary outcomes

  1. icu in hospital mortality

    Time frame: icu patients will be followed over their hospital stay over a maximum period of 6 months

  2. hemoglobin - venous blood gas analysis

    Time frame: hemoglobin will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours

    g/dl

  3. icu ventilation time

    Time frame: icu patients will be followed over their hospital stay over a maximum period of 6 months

    hours/days

Sponsors and collaborators

Lead sponsor

University of Witten/Herdecke

Other

Registry information

Official study title

The Influence of Preoperative Cardiopulmonary Capacity Mesured in MET's (Metabolic Equivalents) on the Perioperative Lactate Level

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Mar 27, 2013
Registry last updated
Sep 17, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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