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Completed

NCT Number: NCT04327258

The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels

Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).

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Key information

Conditions

Anesthesia Surgical Procedure, Operative

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

Bern, 3010, Switzerland

About this study

Background

Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined.

Objective

The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort.

Methods

Cross-sectional association study in a cohort of non-cardiac surgery patients.

This study is a Subproject of a prospective cohort study registered under the ID 041/09.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years and older
  • Written informed consent
  • Scheduled surgery

Exclusion criteria

  • No informed consent
  • Cognitive impairment

Treatment and study plan

Primary outcomes

  1. Influence of NPPA/NPPB haplotype on natriuretic peptide plasma levels

    Time frame: Blood samples collected at start of anesthetic procedure

    Estimation of genetic effects on natriuretic peptide (BNP, NT-proBNP) plasma levels

Sponsors and collaborators

Lead sponsor

Insel Gruppe AG, University Hospital Bern

Other

Registry information

Important dates

Study start
2011
Primary completion
2014
Study completion
2014
First posted
Mar 31, 2020
Registry last updated
Mar 31, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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