Skip to main content
OpenTrials
Completed

NCT Number: NCT01682642

The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis.

In this study of endometriosis patients we compare a common treatment of surgical therapy and medical treatment for 3 months (Zoladex) with patients receiving only surgical therapy. In both cases they immediately start In Vitro Fertilization (IVF) treatment.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Infertility Endometriosis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Urogenital Diseases

Age range

18 year–38 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

AZ Jan Palfijn

Ghent, Oost-vlaanderen, 9000, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • laparoscopical vaporization of endometriosis
  • 1,2, 3e IVF cycle
  • endometriosis stage I and II
  • younger than 38 years

Exclusion criteria

  • endometriosis cysts
  • uterine pathology
  • endocrinological diseases and problems

Treatment and study plan

Zoladex

Drug

after surgical vaporization patients are treated with Zoladex for 3 months before starting IVF treatment

Primary outcomes

  1. Number of Metaphase II Cells (MII)

    Time frame: 3 weeks

    number of MII cells retrieved

Secondary outcomes

  1. Pregnancy Rate

    Time frame: 12 weeks

    The number of ongoing pregnancies obtained which still is the most important issue for the patients.

  2. Good Embryo Quality

    Time frame: 3 days after oocyte retrieval

    The development of the embryo at the time of transfer on day 3. Good quality is defined by more than 7 cells and less then 20% fragmentation on day 3.

  3. Number of Pro Nuclear Cell (2PN)

    Time frame: 1 day after oocyte retrieval

    number of 2PN

  4. Number of Cryopreserved Embryos

    Time frame: 1 week after oocyte retrieval

    number of blastocytes that can be cryopreserved

  5. Total Follicle Stimulating Hormone (FSH) Dose

    Time frame: 3 weeks

    total dose of FSH needed at the end of stimulation

Other outcomes

  1. Number of Days of Stimulation

    Time frame: 3 weeks

    number of days needed before follicles in the ovary are mature for oocyte retrieval

Sponsors and collaborators

Lead sponsor

AZ Jan Palfijn Gent

Other

Collaborators

  • Onze Lieve Vrouw Hospital

Registry information

Official study title

IVF Outcome in Patients With Peritoneal Endometriosis. The Impact of a Hormonal Treatment of the Endometriosis Prior to the IVF on the Pregnancy Rates.

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Sep 11, 2012
Registry last updated
Mar 20, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.