Gonadotropin-releasing Hormone (GnRH) Downregulation Versus Oral Anticonception Prior to ART in Postoperative Endometriosis Patients

Does prolonged GnRH downregulation prior to ART improve the clinical pregnancy rate in postoperative endometriosis patients? (A single centre randomised controlled trial)

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Key information

Conditions

Endometriosis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Infertility Urogenital Diseases

Age range

18 year–39 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

UZ Leuven

Leuven, 3000, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

histologically proven endometriosis with complete treatment of all endometriosis lesions during laparoscopy
only first three ART cycles
normal uterine cavity
Eligible for ovarian stimulation with long agonist protocol

Exclusion criteria

FSH>20 IU/L
presence of large intramural fibroids (> 3 cm)
<4 oocytes obtained in any previous fresh ART cycle
ART with sperm derived from testicular biopsy
ART with Preimplantation Genetic Diagnosis/Screening

Treatment and study plan

Triptorelin

Drug

gonadotropin-releasing hormone (GnRH) agonist

Other names: decapeptyl

ethinylestradiol + dienogest

Drug

oral oestroprogestogen

Other names: Louise

Primary outcomes

clinical pregnancy rate per initiated ART cycle

Time frame: participants will be followed for the duration of the ART cycle including the pregnancy test, an expected average of 10 weeks in the active comparator group and an expected average of 18 weeks in the experimental group

Sponsors and collaborators

Lead sponsor

Universitaire Ziekenhuizen KU Leuven

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2017
Study completion: 2018
First posted: Mar 27, 2015
Registry last updated: Jul 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed