Skip to main content
OpenTrials
Completed

NCT Number: NCT05680532

The Improvement of Black Raspberry in Obese and Mild AZ Patients Infected With H. Pylori

The current study was designed to check the impact of black raspberry (BR) on obese and mild Alzheimers (AZ) patients infected with Helicobacter pylori (H pylori). Through checking various parameters including anthropometric, antioxidants, and CDR.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia H Pylori Infection Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chung Shan Medical University

Taichung, 40201, Taiwan

About this study

The current study was designed to check the impact of black raspberry (BR) on obese and mild Alzheimers (AZ) patients infected with Helicobacter pylori (H pylori).

Preclinical studies (In vitro model) were conducted using 3T3-L1 adipocyte cells to check the anti-adhesion activity of BR.

For the clinical trial, a total of 21 obese mild AZ patients were recruited and separated into 2 groups: Experimental (BR group) and Placebo group.

Experimental group and Placebo group subjects were requested to take either 50 g of BR or 50 g of dextrin respectively for 4 weeks.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI ≧ 27, Waist circumference: men ≧ 90cm, women ≧ 80cm,
  • Body fat: male ≧ 25%, female ≧ 30%,
  • UBT 13C test value> 10‰ (H. pylori (+)),
  • CDR (clinical dementia rating) = 0.5

Exclusion criteria

  • BMI< 27
  • Severe chronic diseases (liver disease, cardiovascular disease, kidney disease)
  • Alcohol abuse
  • Smoking habit
  • Taking berry-related supplementation or any known allergies related to berries.
  • Subjects with prior history of H. pylori infection were treated with triple therapy.

Treatment and study plan

Black raspberry

Dietary Supplement

Experimental group subjects were requested to take 50 g of Black Raspberry powder for 4 weeks.

Placebo

Other

Placebo group subjects were requested to take 50 g of dextrin for 4 weeks.

Primary outcomes

  1. Glycemic indices

    Time frame: 8 weeks

    No significant changes in any of the glycemic indices

  2. Anthropometric parameters

    Time frame: 8 weeks

    BMI were significantly altered

Sponsors and collaborators

Lead sponsor

Chung Shan Medical University

Other

Registry information

Acronym: BR

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jan 11, 2023
Registry last updated
Jan 11, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.