The Impact of Supplementation With Novel Prototype Nutrition Bar on Nitric Oxide Bioavailability and Measures of Athlete Performance

Inclusion criteria

• Male and female participants in self-reported good general health as assessed by the standard procedures described below and specifically meeting the following blood pressure (BP) and body mass index (BMI) ranges: systolic BP: 100-140 mmHg; diastolic BP: 60-90 mmHg; and BMI 18.5-30.
• 18-40 years of age
• Physically active. Determined by meeting the following criteria: completes vigorous physical activity (i.e. activities that take hard physical effort and make you breathe much harder than normal; e.g. heavy lifting, digging, aerobics, fast cycling, running etc) at least 2 x per week and moderate physical activities (i.e. activities that take moderate physical effort and make you breath somewhat harder than normal; for example: carrying light loads, cycling at a regular pace, playing doubles tennis) at least 3 x per week.
• Understanding of the procedures to be undertaken as part of the study
• Willingness to participate in exercise testing and follow supplementation guidelines and other instructions provided by the experimenter
• Informed, voluntary, written consent to participate in the study

Exclusion criteria

• Known pulmonary, cardiovascular or metabolic disease
• Food allergies including phenylketonurea (PKU)
• Current regular use of any dietary supplement (excluding macronutrient based supplements) or previous use of any dietary supplement in the past 6 months that is known to have a lasting effect.
• Blood donation within 3 months prior to the start of the study
• Substance abuse within 2 years of the start of the study
• Smoking
• Any prescription and non-prescription medication which may impact saliva production (antidepressants, diuretics, analgesics, antihistamines, anti-hyper/hypo-tensives, anti-anxiety, appetite suppressants).
• Current or previous use of phosphodiesterase 5 (PDE5) inhibitors.
• Participation in another clinical trial within past 4 weeks.
• Participation in another PepsiCo study within the past 6 months.
• Highly trained or elite endurance athlete as determined by current or recent (within 3 months) participation in an endurance sport at international or national level.
• Pregnancy