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Completed

NCT Number: NCT06218953

The Impact of Preoperative Anemia on Postoperative Anemia and Related Nutrient Abnormalities After Bariatric Surgery

This study aims to assess the impact of preoperative anemia status on anemia and related nutrient abnormalities 1 year after bariatric surgery.

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Key information

Conditions

Anemia Bariatric Surgery Hematologic Diseases Hemic and Lymphatic Diseases

Age range

16 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Yuntao Nie

Beijing, 100029, China

About this study

This study aims to assess the impact of preoperative anemia status on anemia and related nutrient abnormalities (ferritin deficiency, vitamin B12 deficiency, folate deficiency, and low transferrin saturation level) at 1 year after bariatric surgery.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent bariatric surgery (sleeve gastrectomy and Roux-en-Y gastric bypass)
  • Age between 16 and 70 years
  • Patients who have complete 1-year follow-up data

Exclusion criteria

  • Baseline renal failure
  • Vegetarian
  • Postoperative bleeding (it was defined as a drop in hemoglobin levels > 3 g/dL or a confirmed blood loss requiring treatment after surgery)

Treatment and study plan

Primary outcomes

  1. Odds ratio (OR) for anemia by preoperative anemia status

    Time frame: 1 year

    Multivariable logistic regression will be performed to assess the association between preoperative anemia and postoperative anemia. Several factors will be adjusted: sex, age, BMI, waist circumference, hip circumference, surgery, smoking, alcohol, hypertension, diabetes, hyperuricemia, hypercholesterolemia, and hypertriglyceridemia.

Secondary outcomes

  1. Percentage of postoperative anemia

    Time frame: 1 year

    Percentage of postoperative anemia,, , and low transferrin saturation level.

  2. Percentage of anemia severity

    Time frame: 1 year

    Percentage of anemia severity (mild: hemoglobin≥110g/L; moderate: hemoglobin≥80g/L; severe: hemoglobin<80g/L).

  3. Percentage of ferritin deficiency

    Time frame: 1 year

    Percentage of ferritin deficiency, which is defined as ferritin less than 30 ng/mL.

  4. Percentage of vitamin B12 deficiency

    Time frame: 1 year

    Percentage of ferritin deficiency, which is defined as vitamin B12 less than 150 pmol/L.

  5. Percentage of folate deficiency

    Time frame: 1 year

    Percentage of folate deficiency, which is defined as folate less than 10 nmol/L.

  6. Percentage of low transferrin saturation level

    Time frame: 1 year

    Percentage of low transferrin saturation level, which is defined as transferrin saturation less than 20%.

Sponsors and collaborators

Lead sponsor

China-Japan Friendship Hospital

Other

Registry information

Important dates

Study start
2017
Primary completion
2024
Study completion
2024
First posted
Jan 23, 2024
Registry last updated
Jul 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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