The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metablism in Middle-aged and Elderly Individuals With Metabolic Disorders.

A randomised, placebo-controlled, parallel group study to assess the efficacy and safety of NMN in middle-aged and elderly people with immunosenescence. People aged 50-70 years will be included in the study. Participants will be given NMN SR tablets (1000mg/tablet) or placebo, 1 tablet daily before breakfast. The study treatment period lasts 26 weeks. Investigator visits will be conducted at months 1, 3 and 6. Percentage of CD3+CD8+CD27-CD28- cells to total CD3+CD8+ T cells will be used as the primary evaluation metrics for assessing efficacy.Liver fat content, body composition analysis, pancreatic β-cell function, telomere length, fasting blood glucose, glycosylated hemoglobin, and cardiorespiratory fitness will be used as secondary indicators for efficacy assessment. Physiological and biochemical parameters such as blood and urine routine, liver and kidney function will be used for safety assessment.

Inclusion criteria

• Age 50-70 years with overweight or obesity (BMI 24kg/m2);
• At least one of the following three: metabolism-related fatty liver disease (diagnosed by ultrasound); pre-diabetes; type 2 diabetes mellitus with HbA1c <7% without glucose-lowering drug therapy;
• Agreed to participate in the trial and could adhere to the follow-up and visit the hospital on their own; signed the informed consent form.

Exclusion criteria

• Patients with tumours;
• Patients with autoimmune diseases (excluding Hashimoto's thyroiditis);
• Severe cardiovascular disease or cardiac insufficiency;
• Systolic blood pressure > 160 mmHg or diastolic blood pressure > 100 mmHg;
• Chronic obstructive pulmonary disease;
• Chronic active hepatitis or cirrhosis;
• Chronic renal insufficiency;
• Stroke patients
• Severe haematological diseases;
• Infectious diseases;
• Mental illness;
• Other conditions that, in the opinion of the investigator, may affect the results of the study;
• Those who have used NMN or other anti-aging agents within six months.
• Premenopausal woman
• ALT, AST values are more than three times higher than the upper limit of the normal reference range