Exploratory Study on Infection and Immunosenescence Based on an Elderly Clinical Cohort

Inclusion criteria

for the Healthy Control Group

• No clinical symptoms suggestive of infection, including fever, cough, dyspnea, fatigue, or myalgia.
• No abnormal physical signs, including lymphadenopathy, hepatomegaly, splenomegaly, or skin rash.
• Normal laboratory test results, including complete blood count (CBC), C-reactive protein (CRP), and liver and renal function tests.
• Healthy adults without underlying chronic diseases, no history of infectious diseases within the previous 6 months, and generally normal cognitive function.
• Male or female.
• Able to understand the study procedures and voluntarily provide written informed consent.

Inclusion criteria

for the Infection Group 1.Age: 60 years or older; no gender restrictions. 2. Clinically diagnosed with an infectious disease by the treating physician. 3. The participant provides informed consent and signs the relevant documents.

-------------- Exclusion Criteria for the Healthy Control Group

• Refusal to participate in the study;
• Any other condition that, in the opinion of the investigator, makes the participant unsuitable for enrollment.

Exclusion criteria

for the Infection Group

• Final primary diagnosis is a non-infectious disease (e.g., connective tissue disease, tumor, or other conditions).
• Positive culture results are determined by the clinician to be due to colonization or contamination rather than infection.
• Refusal to participate in the study.
• Patients in critical or severe conditions who are unable to cooperate with sample collection.
• Other conditions deemed unsuitable for inclusion as determined by the researchers.