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Completed

NCT Number: NCT07146399

The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function

Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action. In recent years, IPC has gradually been applied to enhance athletic performance and accelerate postexercise recovery; however, there has been limited research on the effects of IPC on ANS function and competitive condition before and after exercise. This study investigated the effects of IPC on ANS function before and after sport-specific testing in taekwondo athletes. The objectives of our study are (1) to investigate the impact of IPC on two indicators of autonomic nervous function-HRV and HRR-and (2) to reveal the coordinating effect of IPC on the sympathetic and parasympathetic nervous systems during the warm-up phase and after specific testing in taekwondo athletes. The investigators hypothesize that IPC enhances sympathetic drive during the warm-up phase and rapidly activates the parasympathetic nervous system postexercise, which is accompanied by improvements in the athletes' competitive condition.

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Key information

Conditions

Ischemic Preconditioning Autonomic Nervous System (ANS) Functioning and Mood State

Age range

18 year–22 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Guangzhou Sport University

Guangzhou, Guangdong, 510500, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Taekwondo athletes with a national ranking of level two or higher, including those placed in the top three at the Provincial Professional Taekwondo Championship (combat) and the top eight at the National Professional Taekwondo Championship (combat);
  • adult males aged 18 years or older;
  • regular participation in specialized Taekwondo training for the past three months.
  • All the subjects were from the same team.

Exclusion criteria

  • consumption of alcohol or caffeine within 24 hours prior to the experiment;
  • engagement in strenuous physical activity within 24 hours before the experiment;
  • presence of acute or chronic diseases, including cardiovascular diseases, anxiety disorders, and metabolic diseases;
  • use of creatine supplements

Treatment and study plan

Ischemic preconditioning

Procedure

Compression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) *4. 220 mmHg

Sham (No Treatment)

Procedure

Compression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) *4. 20 mmHg

Primary outcomes

  1. Taekwondo-specific sports performance test.

    Time frame: Five minutes after the intervention, a standard warm-up lasting 10 minutes is conducted. Following the warm-up, a rest period of 5 minutes is observed. Subsequently, three sets of specialized sports performance tests are administered, with each set lasti

    The specialized athletic ability in Taekwondo is measured by the number of kicks performed during the test.

  2. Heart rate variability

    Time frame: The measurement time points were as follows: heart rate variability was assessed in the resting state upon participants' arrival at the testing site, after a warm-up, and following the sport-specific performance test.

    Used to measure the autonomic nervous function of taekwondo athletes.

  3. Heart rate recovery

    Time frame: The measurement time points were established as follows: heart rate recovery was assessed for 1 minute during the intervals of each test group. Additionally, heart rate recovery was recorded at both 1 minute and 5 minutes following the completion of thre

    Used to measure the autonomic nervous function of taekwondo athletes.

  4. Blood lactate

    Time frame: Blood lactate measurements were taken at several key time points during the study: upon participants' arrival at the test site while they were in a quiet state; at the 3rd minute following the conclusion of the intervention; prior to the commencement of

    Used to measure the intensity and metabolic adaptations during the testing process of taekwondo athletes.

Sponsors and collaborators

Lead sponsor

Ziyue Ou

Other

Collaborators

  • Guangzhou Sport University

Registry information

Official study title

Ischemic Preconditioning Enhances Autonomic Nervous System Modulation During Frequency Speed of Kick Test in Taekwondo Athletes: A Randomized Crossover Study

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Aug 28, 2025
Registry last updated
Aug 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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