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Completed

NCT Number: NCT05514197

The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty

The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.

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Key information

Conditions

Ascorbic Acid Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Pain Signs and Symptoms

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chi Mei Medical Center

Tainan, Tainan City, 701, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physical status according to American Society of Anesthesiologists (ASA) I-III
  • Patients scheduled for total knee arthroplasty
  • Patients aged ranging from 50 to 80 years old

Exclusion criteria

  • Previous operation on the same knee
  • Allergy or intolerance to one of the study medications
  • Coagulopathy
  • Having lower limbs neuropathy
  • End-organ failure (CKD stage IV or V, NYHA III or IV)
  • BMI > 35
  • Chronic opioid use (>3 months) or drug abuser
  • Difficulty in communication (Impaired mental status)
  • Hyperuricemia or Glucose-6-phosphate dehydrogenase deficiency patient

Treatment and study plan

Ascorbic acid 100mg/kg, Maximus 10g

Drug

Intravenous loading of 100mg/kg ascorbic acid with normal saline, totally 100ml Completed before induction

Control Rx

Drug

Intravenous loading 100ml normal saline

Primary outcomes

  1. Numeric rating scale for pain

    Time frame: 15 minutes postoperatively

    11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain

  2. Numeric rating scale for pain

    Time frame: 1 hour postoperatively

    11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain

  3. Numeric rating scale for pain

    Time frame: 6 hours postoperatively

    11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain

  4. Numeric rating scale for pain

    Time frame: 24 hours postoperatively

    11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain

  5. Numeric rating scale for pain

    Time frame: 48 hours postoperatively

    11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain

  6. Numeric rating scale for soreness (Sngception)

    Time frame: 15 minutes after surgery

    11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness

  7. Numeric rating scale for soreness (Sngception)

    Time frame: 1 hours postoperatively

    11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness

  8. Numeric rating scale for soreness (Sngception)

    Time frame: 6 hours postoeratively

    11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness

  9. Numeric rating scale for soreness (Sngception)

    Time frame: 24 hours postoperatively

    11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness

  10. Numeric rating scale for soreness (Sngception)

    Time frame: 48 hours postoperatively

    11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness

Secondary outcomes

  1. Morphine consumption

    Time frame: 48 hours postoperatively

    Amount of IV morphine consumption postoperatively

  2. Time to first rescue morphine requirement at post-anesthetic care unit

    Time frame: up to 2 hours

    Duration from arriving post-anesthetic care unit to requiring first morphine injection

  3. Severity of postoperative nausea/ vomiting and dizziness

    Time frame: 48 hours postoperatively

    From 0 to 5, 0: non, 1: mild, 2: moderate, 3: severe, 4: unbearable

Other outcomes

  1. Blood ascorbic acid concentration

    Time frame: Preoperative baseline and postoperative day1

    Blood ascorbic acid analysis

  2. PostOP Knee joint range of motion

    Time frame: 72 hours postoperatively

    In degree from zero to 170

Sponsors and collaborators

Lead sponsor

Chimei Medical Center

Other

Registry information

Official study title

The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty.

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
Aug 24, 2022
Registry last updated
Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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