The Impact of Dental Health on Complications During and Following Radiotherapy in the Head and Neck Region.

Study the risk of complications after dental extractions in patients recieving radiotherapy.

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Key information

Conditions

Head and Neck Neoplasms Extracting Own Teeth Neoplasms Neoplasms by Site Radiotherapy; Complications

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Oral and Maxillofacial department

Lund, Skåne County, Sweden

About this study

Dental extractions before radiotherapy in the head and neck region is an established part of the treatment plan for patients with malignant disease. There are contradictory results in the literature regarding the importance timing and magnitude of extractions. It is important to minimize complications in this patient group since the regular therapy is already detrimental to the affected tissues. Patients were extracted from the ARTSCAN register were the population was followed for 4 years for several factors, including development of osteoradionecrosis. The aim is to evaluate which diagnoses are more prone to develop complications after extraction. If there is a relationship between occurrence of complication and magnitude of dental pathology.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Malignant diagnosis
radiotherapy pre or postoperative

Exclusion criteria

Treatment and study plan

Dentoalveolar surgery

Procedure

Surgery to extract teeth

Primary outcomes

Does dental extractions increase the risk for complications such as osteoradionecrosis?

Time frame: From diagnosis of head and neck pathology, approximately 1 month before start of radiotherapy, and to the end of the medical record which may be from one year after the oncologic treatment up to 26 years after oncologic treatment.

Type of complication when extracting teeth in conjunction with radiotherapy.
Does dental pathology in extracted teeth correlate with development of osteoradionecrosis?

Time frame: From diagnosis of head and neck pathology, approximately 1 month before start of radiotherapy, and to the end of the medical record which may be from one year after the oncologic treatment up to 26 years after oncologic treatment.

Are any specific dental pathology more prone to develop complications than others?

Sponsors and collaborators

Lead sponsor

Lund University Hospital

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2025
First posted: Feb 21, 2025
Registry last updated: Feb 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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