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OpenTrials
Completed

NCT Number: NCT05218824

Collection of Head Images During Radiotherapy

The primary objective of this observational study is to quantify the translation, rotation, and deformation of patient head positions of head and neck cancer patients over the course of a radiation therapy treatment for head and neck cancer. This objective will be achieved by comparing X-ray images collected during each treatment session with those obtained from the planning CT scan. Secondary objectives include (1) the use of the collected X-ray images to develop realistic artificial X-ray images where patient movement can be simulated and (2) to determine whether motion can be detected from individual X-ray images acquired during radiation therapy treatment.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Blacktown Hospital

Blacktown, New South Wales, 2148, Australia

About this study

Participants will undergo their radiation therapy treatment for HNC as planned and per the routine clinical management protocol. As part of this routine treatment, multiple x-ray images will be acquired to assist in accurate positioning of the patient for their planned radiation therapy. Normally these images are stored for a few days and then discarded. This study will be collating, storing and analysing these images. These X-ray images will be paired with the corresponding pre-treatment CT scan that is routinely acquired for each patient, as well as the locations of organs of interest, such as the tumour and surrounding structures. The patient treatment plan will also be collated, as it will allow for analysis of how any motion affects the accuracy of dose delivery. The patient radiation treatment delivery record will be collected to help sort and categorise the acquired images. Information on potential confounding or interacting factors will be collected: demographic information will be collected including sex, age, tumour stage and histology.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • A diagnosis of head and neck cancer (any stage)
  • Age 18 years or greater
  • Receiving radiation therapy to the head and neck with a thermoplastic immobilisation mask
  • An ECOG score in the range of 0 to 2
  • Any other prior or concurrent therapy allowed

Exclusion criteria

  • People with cognitive impairment which would preclude them from providing informed consent
  • People who are unable to speak and read English and for whom obtaining consent would be difficult.

Treatment and study plan

Primary outcomes

  1. Translational head motion between different radiation therapy treatment sessions

    Time frame: 8 weeks

    Translation error (mm)

  2. Rotational head motion between different radiation therapy treatment sessions

    Time frame: 8 weeks

    Rotation error (degree)

  3. Head deformation between different radiation therapy treatment sessions

    Time frame: 8 weeks

    Deformation error (mm)

Secondary outcomes

  1. Difference in structural similarity (SSIM) indexes between artificial and real X-rays

    Time frame: 8 weeks

    Image quality metric: Structural Similarity (SSIM) index.

  2. Difference in mean absolute error between artificial and real X-rays

    Time frame: 8 weeks

    Image quality metric: Mean Absolute Error.

Sponsors and collaborators

Lead sponsor

University of Sydney

Other

Collaborators

  • Western Sydney Local Health District

Registry information

Official study title

Collection of Head Images During Radiotherapy (CHIRP)

Acronym: CHIRP

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Feb 1, 2022
Registry last updated
May 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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