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Recruiting

NCT Number: NCT06860698

The Impact of Chronic E-Cigarette Usage on Microvascular Health

The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.

Recruiting

Interested in participating?

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Key information

Age range

18 year–29 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Virginia Commonwealth University

Richmond, Virginia, 23298, United States

Location status: Recruiting

Location contact

Paula Rodriguez Miguelez

CONTACT

[email protected]

804-396-4498

About this study

Electronic cigarettes or e-cigarettes have become increasingly popular, due to their promotion as a healthy alternative to traditional tobacco cigarettes. However, there are large discrepancies of knowledge in understanding how these e-cigarettes affect the subjects health and the way their body uses oxygen. The overall goal of this study is to evaluate e-cigarettes usage on subjects health.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

e-Cig users arm

Inclusion criteria

  • Between 18 and 29 years of age
  • Used e-cigarettes with nicotine (≥3 times/week for ≥6 months)

Exclusion criteria

  • 17 years old and younger or 30 years old or older.
  • Former combustible tobacco user/ former smoker
  • Use of cigarettes for 15 days or more in the past 60 days
  • Use of other tobacco products (cigars, hookah, smokeless), marijuana and/or illicit or prescription drugs weekly or more frequently in the past 60 days
  • Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
  • Disorder or use of medication that affects cardiopulmonary health
  • Evidence of pregnancy or current nursing

Non e-Cig using arm

Inclusion

  • Between 18 and 29 years of age

Exclusion

  • 17 years old and younger or 30 years old and older
  • Use of cigarettes or other tobacco products more than 50 times in their lifetime.
  • Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
  • Disorder or use of medication that affects cardiopulmonary health
  • Evidence of pregnancy or current nursing

Treatment and study plan

E-cig use

Other

Based on e-cigarette usage, participants will be divided into those who used e-cigarettes and those who did not use e-cigarettes

Primary outcomes

  1. Endothelial dependent dilation

    Time frame: Participation is one week

    Endothelial-dependent dilation will be assessed using laser doppler speckle contrast in both groups through the intervention

  2. Neurogenic response

    Time frame: Participation is one week

    Neurogenic response will be assessed using axon reflex in both groups through the intervention

Study contacts

Contact information is provided by the study sponsor or research team.

Paula Rodriguez Miguelez

CONTACT

[email protected]

(804) 396-4498

Sponsors and collaborators

Lead sponsor

Virginia Commonwealth University

Other

Registry information

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Mar 6, 2025
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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