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NCT Number: NCT03792659

The EXPLORE MG Registry for Myasthenia Gravis

The purpose of this study is to create a Yale University Department of Neurology Myasthenia Gravis (MG) registry that will be used for current and future research projects involving the study of Myasthenia Gravis.

Recruiting

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Key information

Conditions

Myasthenia Gravis Autoimmune Diseases Autoimmune Diseases of the Nervous System Immune System Diseases Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms Neurodegenerative Diseases Neuromuscular Diseases Neuromuscular Junction Diseases Paraneoplastic Syndromes Paraneoplastic Syndromes, Nervous System

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States

Location status: Recruiting

Location contact

Bailey Munro Sheldon, PhD

CONTACT

[email protected]

203-737-7095

Richard Nowak, MD, MS

PRINCIPAL_INVESTIGATOR

About this study

This registry will allow for the research of several mechanisms of Myasthenia Gravis (MG) by studying peripheral blood, stool, disease status and course, and treatment of subjects with MG. The EXPLORE-MG Registry focuses on varied aspects of MG such as disease management, health care utilization, health costs, disease characteristics, and diagnostic tools. As such, it will aid in a broader understanding of MG, while providing a registry from which questions about the disease may be better answered.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients diagnosed with Myasthenia Gravis presenting to the Yale Department of Neurology for clinical care or research interventions will be invited to donate their biological specimens/clinical data.

Exclusion criteria

  • Failure to meet the Inclusion Criteria.

Treatment and study plan

Blood Sample Draw

Other

Approximately 100 cc (less than 1/2 cup) of blood will be drawn from both groups.

Primary outcomes

  1. The number of successful blood draws will be reported at the conclusion of the sample collection

    Time frame: 8 years

    Successful Collection of Blood

Secondary outcomes

  1. The number of stool samples collected will be reported at the conclusion of the sample

    Time frame: 8 years

    Count of Stool Samples

Study contacts

Contact information is provided by the study sponsor or research team.

Bailey Sheldon, PhD

CONTACT

[email protected]

203-737-7095

Sponsors and collaborators

Lead sponsor

Yale University

Other

Registry information

Official study title

Exploring Outcomes and Characteristics of Myasthenia Gravis: The EXPLORE MG Registry

Important dates

Study start
2016
Primary completion
2026
Study completion
2026
First posted
Jan 3, 2019
Registry last updated
Nov 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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