The Electroencephalographic Mechanisms of Anesthesia and Human Consciousness

Inclusion criteria

• Age range: 1 - 65 years old
• BMI: 18.5 - 25.0 kg/m²
• ASA physical status classification: I - III
• Patients diagnosed with drug - refractory epilepsy who, after long - term monitoring of epileptic seizures, require stereo-electroencephalography (SEEG) electrode implantation based on the clinical need for monitoring their epilepsy.
• Patients voluntarily participate in this study and sign a written informed consent form.

Exclusion criteria

• Patients with severe arrhythmia or other organic heart diseases;
• Patients with comorbid obstructive sleep apnea-hypopnea syndrome (OSAHS);
• Patients with hepatic or renal dysfunction; those with a history of immunodeficiency diseases , or a history of cancer/malignant tumors, or a history of autoimmune diseases, or severe cardiovascular and cerebrovascular diseases, or other diseases that may significantly reduce life expectancy;
• Patients with any history of diseases that may affect protocol compliance (such as severe mental disorders, disturbance of consciousness; cognitive dysfunction, drug abuse or addiction, etc.);
• Pregnant or lactating women, or those of childbearing potential who are unwilling/unable to take effective contraceptive measures;
• Patients with known allergies to the ingredients contained in the drugs used in this study;
• Patients who have participated in any drug clinical trial within 6 months before the screening examination;
• Patients who are deemed unsuitable to participate in this study by the researcher.