The Effect of phoSPHocreatine on mEdical Emergency Team (Met) tREated Patients

Inclusion criteria

• Admitted in hospital (but outside ICU)
• Age>=18 years
• Written informed consent
• Serum creatinine <=2 mg/dl
• Patient with impending or underlying cardiac failure or cardiac arrest, irrespectively of the primitive organ failure, and the Medical Emergency Team (MET) is called upon at least one of the following:

• Threatened airways;
• Respiratory arrest;
• Respiratory rate <5 or >36 breaths per min;
• Pulse rate <40 or >140 beats per min;
• Systolic blood pressure < 90 mm Hg;
• Sudden fall in level of consciousness;
• Fall in Glasgow coma scale of > 2 points.

Exclusion criteria

• Age < 18 years;
• Ongoing cardiac massage;
• Current hospital admission from a care nursing facility;
• Planned discharge to a care nursing facility;
• Reasons for withdrawal of life-sustaining therapy;
• History of kidney transplantation;
• Solitary kidney (by any reason);
• Serum Creatinine > 2 mg/dl;
• Immediate need for ICU admission;
• Known allergy to PCr;
• Pregnancy;
• Previous enrollment and randomization into this trial;
• Administration of PCr in the previous 30 day.