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Completed

NCT Number: NCT06362005

The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus

evaluate clinically and biochemically the efficacy of topically applied selenium as complementary or alternative to triamcinolone acetonide 0.1% and tacrolimus 0.1% in patients with oral lichen planus.

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Key information

Conditions

Lichen Planus, Oral Lichen Planus Lichenoid Eruptions Mouth Diseases Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Stomatognathic Diseases

Age range

20 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Alazhar university ,faculty of Dental Medicine

Asyut, 0000, Egypt

About this study

The signs and symptoms of the oral lichen planus lesion. 2-The associated oral symptoms. 3- Glutathione biomarker level as an antioxidant enzyme in saliva by ELISA analysis .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • clinical diagnosis of OLP

Exclusion criteria

  • lichenoid reaction from medication ' .
  • any systemic autoimmune disease
  • Pregnancy
  • smokers

Treatment and study plan

Triamcinolone Acetonide 0.1% Oint

Drug

RCT

Other names: Group I

Tacrollimus Topical

Drug

RCT

Other names: Group II

selenium

Drug

RCT

Other names: Group III

Selenium & Triamcinolone Acetonide 0.1% Oint

Drug

RCT

Other names: Group IV

Selenium& Tacrollimus topical

Drug

RCT

Other names: Group V

Primary outcomes

  1. to assess a visual analog scale (VAS)of the oral lichen planus lesion

    Time frame: baseline, 1, 3 and 6 months after treatment

    qualitative

Secondary outcomes

  1. to assess The associated Oral Disease Severity Score 3- Glutathione biomarker level as an antioxidant enzyme in saliva by ELISA analysis

    Time frame: baseline, 1, 3 and 6 months after treatment

    qualitative ,and quantitiave

  2. Biochemical evaluation of salivary Glutathione level using (ELISA)

    Time frame: baseline, 1, 3 months after treatment

    Quantity

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Collaborators

  • Sphinx university

Registry information

Official study title

The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus (Randomized Clinical Trial)

Acronym: RCT

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Apr 12, 2024
Registry last updated
Dec 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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