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NCT Number: NCT06784869

The Efficacy of Scaling and Root Planing on Endothelin-1 Level

Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.

Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy.

Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.

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Key information

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.

Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy.

Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • systemically healthy
  • Generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm)

Exclusion criteria

  • subjects who wore dental prosthesis
  • teeth with grade II mobility,
  • alcoholic and smoker, had treated caries
  • underwent periodontal therapy within the last four months

Treatment and study plan

Scaling and root surface debritment

Device

Patients with 4-6 mm pocket depth were participated in this study; clinical periodontal parameters (BOP, PLI, PPD, CAL) were recorded at the baseline visit. To ensure sampling accuracy, From the site two papers with GCF were sampled. Following sample collecting for GCF, Every patient received comprehensive mouth supragingival scaling with an ultrasonic scaler (WoodpEEKer® UDS-K) along with dental hygiene recommendations. One week later, the sites were irrigated with normal saline after being scaled and root planed (ScRp) with Gracey curette. Following completion of subgingival instrumentation, each patient returned to the clinic following 1 and 3 months for periodontal parameter recording and GCF collection. Throughout these sessions, every patient received reinstruction to engage in self-oral hygiene practices.

Other names: Scaling and root planing

Primary outcomes

  1. PPD

    Time frame: 3 months recall visits

    changes in PPD after non-surgical periodontal treatment.

  2. CAL

    Time frame: 3 months recall visits

    changes in CAL after non-surgical periodontal treatment.

Secondary outcomes

  1. ET-1

    Time frame: 3 months recall visits

    change in GCF level of Endothelin-1 in 1- and 3- month following the periodontal treatment

Study contacts

Contact information is provided by the study sponsor or research team.

Sarah alrihaymee

CONTACT

[email protected]

07828802375

Sponsors and collaborators

Lead sponsor

University of Baghdad

Other

Registry information

Official study title

The Efficacy of Scaling and Root Planing on Endothelin-1 Gingival Crevicular Fluid Levels Among Periodontitis Patients: a Randomized Clinical Trial

Acronym: clinical

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jan 20, 2025
Registry last updated
Jan 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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