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NCT Number: NCT07482878

Tinder Fungus as an Adjunct to Non-surgical Periodontal Therapy for Periodontitis

The goal of this interventional clinical study is to learn if a Tinder fungus-based formulation -specifically a toothpaste and oral supplement powder-works as adjuncts to non-surgical periodontal therapy (NSPT) in patients with periodontitis.

The main questions it aims to answer is:

• Does the Tinder fungus-based formulation as an adjunct to NSPT reduce bleeding on probing more than a commercially available toothpaste as an adjunct to NSPT? Researchers will compare tinder fungus toothpaste and oral powder as an adjunct to NSPT to a commercially available toothpaste as an adjunct to NSPT to see if the Tinder fungus-based formulation works as adjuncts to NSPT in patients with periodontitis.

Participants will:

* Take tinder fungus toothpaste and oral powder or a commercially available toothpaste as an adjunct to NSPT twice daily for 30 consecutive days * Visit the clinic at least twice including a visit before and after the intervention * Keep a diary documenting their well-being and the number of times they used the toothpastes in the morning and evening.

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dental Clinic of the Sigmund Freud Private University

Vienna, State of Vienna, 1020, Austria

Location contact

Brenda Laky, PD,MSc,PhD

PRINCIPAL_INVESTIGATOR

Hady Haririan, Prof,Dr,PhD,MSc

CONTACT

[email protected]

+4317201966

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with Stage III or IV periodontitis
  • Patients who have not yet initiated periodontal therapy
  • Patients who have at least 20 remaining teeth
  • Patients who are willing to use an electric toothbrush
  • Patients who are willing to use interdental brushes

Exclusion criteria

  • Patients who have previously received treatment for periodontitis
  • Patients who have already undergone or initiated periodontal therapy
  • Patients with a known allergy or intolerance to any component of the toothpaste or the powder
  • Patients who are already using a product that contains tinder fungus (Fomes fomentarius)
  • Patients who, at the time of periodontal treatment, are undergoing active systemic cancer therapy (e.g., chemotherapy or immunotherapy) or radiotherapy in the head and neck region, or for whom such therapy is planned. Previous illnesses or completed therapies do not constitute an exclusion criterion, provided that no current or planned treatment exists that could influence the periodontal treatment outcome or pose an increased risk for the participants.

Treatment and study plan

Tinder fungus-based formulation

Other

Participants will receive Tinder fungus (Fomes fomentarius)-based formulations including a toothpaste plus an oral supplement powder as adjuncts to non-surgical periodontal therapy (NSPT).

Commercially available toothpaste

Other

A standard commercially available toothpaste administered as an adjunct to NSPT.

Primary outcomes

  1. Bleeding on probing (BoP in %) change

    Time frame: changes from baseline (T0; 1 day before intervention starts) to reevaluation (T1; 5 weeks (±1 week) after intervention start)

    Bleeding on probing (BoP in %) changes from baseline (T0) to reevaluation (T1). BOP will be recorded as yes/no for each of 6 sites and reported as the percentage of affected sites per participant.

Sponsors and collaborators

Lead sponsor

Sigmund Freud PrivatUniversitat

Other

Registry information

Official study title

Tinder Fungus (Fomes Fomentarius) as an Adjunct to Non-surgical Periodontal Therapy for Periodontitis: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Mar 19, 2026
Registry last updated
Jul 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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